Senior Principal Scientist | Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead

BioSpace; Thousand Oaks (CA); On-site; USD 120,000 - 160,000; Full time

Benefits offered by this job

Comprehensive benefits package

Discretionary annual bonus

Stock-based incentives

Flexible work models

Award-winning time-off plans

Job summary

A leading biotechnology firm in Thousand Oaks, California seeks a Senior Principal Scientist to lead bioanalytical strategies, focusing on antibody‑siRNA conjugates. The ideal candidate will possess a doctorate in pharmacology and relevant experience in ADME and pharmacokinetics. Responsibilities include leading innovative research and collaborating with multidisciplinary teams to drive therapeutic advancements. Competitive benefits and salary structures are offered to support professional growth. Apply now to make a significant impact in biotechnology.

Qualifications

• 3+ years of industry experience with a doctorate in pharmacology.
• 6+ years of industry experience with a master's degree.
• 8+ years of industry experience with a bachelor's degree.

Responsibilities

• Lead the strategy for innovative bioanalytical platforms.
• Design and interpret results from in vivo studies.
• Mentor and cross-train scientific colleagues.

Skills

Knowledge of antibody‑siRNA conjugate ADME

Experience with biochemistry

Exceptional communication skills

Education

Doctorate degree in pharmacology or related field

Master’s degree in pharmacology or related field

Bachelor’s degree in pharmacology or related field

Tools

LC/MS bioanalytical platforms

RT‑qPCR

Immunoassay

Job description

Senior Principal Scientist - Antibody‑siRNA Bioanalytical & Biodistribution Strategy Lead

Join Amgen’s mission of serving patients living with serious illnesses. Since 1980, Amgen has helped pioneer the world of biotechnology in the fight against the world’s toughest diseases. With a focus on Oncology, Inflammation, General Medicine, and Rare Disease, we reach millions of patients each year. As a member of the Amgen team, you will help make a lasting impact on the lives of patients while advancing innovative medicines.

What You Will Do

In this vital role you will be part of the Pharmacokinetics & Drug Metabolism Bioanalytical Sciences (PKDM‑BA) team to advance our growing siRNA research portfolio. You will lead the strategy and execution of innovative bioanalytical platforms to measure antibody‑siRNA conjugates in preclinical samples, both in vitro and in vivo, for characterizing ADME and elucidating pharmacokinetic‑pharmacodynamic relationships. In addition to leading teams within PKDM‑BA, you will be a project team representative contributing to multidisciplinary teams composed of experts in chemistry, biology, toxicology, clinical pharmacology and similar disciplines to drive clinical candidate selection and successfully file regulatory applications.

• Lead strategy to establish innovative bioanalytical platforms to measure antibody‑siRNA conjugates in preclinical samples (in vitro and in vivo)
• Lead strategy to establish innovative in vitro ADME assays for antibody‑siRNA conjugates
• Design, execute, and interpret results from in vivo studies characterizing pharmacokinetics, pharmacokinetic‑pharmacodynamic relationships, tissue distribution, and toxicokinetics of antibody‑siRNA conjugates
• Represent PKDM‑BA in projects involving antibody‑siRNA conjugates and other siRNA modalities
• Prepare the pharmacokinetic written summary for regulatory applications
• Mentor and cross‑train PKDM‑BA scientific colleagues
• Build and foster cross‑functional collaboration across R&D to advance siRNA therapeutics from discovery to clinical proof of concept

What We Expect of You

We are all different, yet we all use our unique contributions to serve patients. We seek a leader with the following qualifications:

Basic Qualifications

• Doctorate degree in pharmacology, biochemistry or a related‑scientific discipline and at least 3 years of industry experience
• or Master’s degree in the same field and at least 6 years of industry experience
• or Bachelor’s degree in the same field and at least 8 years of industry experience

Preferred Qualifications

• Extensive knowledge of antibody‑siRNA conjugate ADME and pharmacokinetics; experience with other siRNA modalities, antibody‑drug conjugates, peptide conjugates, biologics or small molecules is highly desirable
• Experience investigating biodistribution and metabolism of siRNA conjugated to a tissue‑targeting ligand
• Expertise in antibody‑siRNA bioanalytical approaches and considerations
• Extensive experience with ligand binding assays (immunoassay and hybridization assays) and LC/MS bioanalytical platforms; experience with RT‑qPCR and/or RT‑ddPCR is also desirable
• Exceptional written and verbal communication skills
• Experience with regulatory filings for antibody‑siRNA conjugates or other targeted delivery siRNA therapeutics

What You Can Expect of Us

We support your professional and personal growth and well‑being through competitive benefits, a collaborative culture, and career development opportunities. Salary for this role in the U.S. (excluding Puerto Rico) is posted; actual salary will vary based on skills, experience, and qualifications.

• A comprehensive employee benefits package, including retirement and savings plans, group medical, dental, and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan
• Stock‑based long‑term incentives
• Award‑winning time‑off plans
• Flexible work models where possible

Begin your journey with Amgen today. Apply now and make a lasting impact with the Amgen team.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.