Scientist – Erythroid Biology

Amgen; Thousand Oaks (CA); On-site; USD 110,000 - 170,000; Full time

Job summary

Amgen is seeking a Scientist – Erythroid Biology in Thousand Oaks, CA. The role involves designing and conducting experiments, analyzing results, and presenting study findings within cross-functional drug discovery teams.

The candidate will develop human primary cell-based systems and contribute to IND-enabling studies, with emphasis on siRNA therapeutics and erythroid biology. Amgen offers a comprehensive benefits package and competitive salary.

Qualifications

• Doctorate degree or equivalent in a relevant field.
• Master’s degree with 2+ years of scientific experience or Bachelor's with 4+ years.
• Experience with siRNA/RNA therapeutics and erythroid biology preferred.

Responsibilities

• Design and execute in vitro and ex vivo assays to evaluate siRNA delivery and function.
• Develop human primary cell-based systems.
• Support target validation and mechanism-of-action studies for siRNA therapeutics.
• Collaborate with Delivery/chemistry teams, Translational and biomarker teams.
• Establish and optimize Flow cytometry panels, qPCR / RNA-based readouts.
• Contribute to IND-enabling studies and data packages.

Skills

siRNA delivery

Flow cytometry

Cell-based assays

Cross-functional collaboration

Education

Doctorate degree

Master’s degree + 2 years experience

Bachelor’s degree + 4 years experience

Tools

qPCR

RNA readouts

Job description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist – Erythroid Biology

What You Will Do

Let’s do this. Let’s change the world. In this vital role you will. A Scientist at Amgen is responsible for designing and conducting experiments, analyzing results, and interpreting data. They prepare technical reports, summaries, and protocols and present study results at team meetings. They also assist in maintaining lab equipment, troubleshooting issues, and ensuring safety protocols are adhered to.

Responsibilities

• Design and execute in vitro and ex vivo assays to evaluate siRNA delivery and function
• Develop human primary cell-based systems
• Support target validation and mechanism-of-action studies for siRNA therapeutics
• Collaborate with Delivery/chemistry teams, Translational and biomarker teams
• Establish and optimize Flow cytometry panels, qPCR / RNA-based readouts
• Contribute to IND-enabling studies and data packages

Basic Qualifications

• Doctorate degree
• Master’s degree and 2 years scientific experience
• OR
• Bachelor's degree and 4 years scientific experience

Preferred Qualifications

• Experience with siRNA / RNA therapeutics (delivery or functional assays), Erythroid biology and hematopoiesis.
• Strong background in Flow cytometry (multi-color), Cell-based functional assays
• Familiarity with gene expression (qPCR, RNA assays), target engagement assays Experience working in cross-functional drug discovery teams
• Knowledge on Hemoglobinopathies, conjugated delivery systems, CRISPR or gene editing is a plus

What You Can Expect Of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

External/Internal postings

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Internal only posting (or Pre-ID candidate)

Amgen anticipates accepting applications however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.