Senior Scientist, Plate-Based Analytical Assays

Elanco; Indianapolis (IN); Hybrid; USD 90,000 - 120,000; Full time

Benefits offered by this job

Relocation packages

Two weeklong shutdowns

8-week parental leave

Employee Resource Groups

Annual bonus offering

Flexible work arrangements

401K matching

Job summary

Elanco, headquartered in Indianapolis, is seeking a Senior Associate Scientist in Transitional and Early Development to bridge discovery and clinical development through plate-based analytical assays.

You will design and execute screening assays (receptor blocking ELISAs, AC-SINS, PEG assays), develop robust ELISAs for lead candidates, and prepare methods for tech transfer to Analytical Development, with collaboration across Discovery Research and Analytical Development.

Qualifications

• Experience in developing and optimizing ligand-binding assays (ELISAs).
• Experience screening and characterizing monoclonal antibodies or complex biomolecules.
• Ability to design and evaluate tool reagents for assay development.

Responsibilities

• Perform routine and customized research-stage plate assays, including receptor blocking ELISAs, quantitative ELISAs, AC-SINS, and PEG precipitation assays to screen hit mAbs and other biomolecules.
• Develop, optimize, and qualify quantitative ELISAs for lead candidate molecules.
• Ensure these assays meet early robustness criteria for successful technology transfer to the Analytical Development team at Pipeline Entry.
• Proactively design, source, and evaluate critical tool reagents (e.g., capture/detection antibodies, recombinant target proteins) required for customized ligand-binding assays.
• Analyze large datasets using appropriate statistical and graphing software (e.g., GraphPad Prism, JMP).
• Document all experimental work meticulously in electronic lab notebooks (ELN) and author technical reports.
• Interface daily with scientists across Discovery Research and Analytical Development to ensure assay strategies align with project milestones and molecule characterization needs.
• Evaluate and implement new plate-based technologies and high-throughput automation strategies to improve screening efficiency and data quality.

Skills

Plate-based assay development

ELISA optimization

Data analysis (GraphPad Prism, JMP)

Tool reagent design

Cross-functional collaboration

Strong communication

Education

B.S. or M.S. in Immunology, Biochemistry, Molecular Biology, Cell Biology, or related field

Tools

ELISAs

AC-SINS

PEG assays

GraphPad Prism

JMP

Job description

Elanco, headquartered in Indianapolis, is seeking a Senior Associate Scientist in Transitional and Early Development to bridge discovery and clinical development through plate-based analytical assays.

You will design and execute screening assays (receptor blocking ELISAs, AC-SINS, PEG assays), develop robust ELISAs for lead candidates, and prepare methods for tech transfer to Analytical Development, with collaboration across Discovery Research and Analytical Development.