Senior Scientist - PKDM-BA

Amgen Inc. (IR); South San Francisco (CA); On-site; USD 144,000 - 195,000; Full time

Benefits offered by this job

Retirement & savings plan

Medical, dental, vision coverage

Stock-based incentives

Paid time off

Flexible work models

Job summary

Amgen in the United States seeks a Senior Scientist - PKDM-BA to design and execute biological and biophysical experiments to understand ADME properties of large molecule therapeutics, supporting drug discovery and early development programs.

The role is lab-based with emphasis on assay/technology development, data interpretation, and communicating results to project teams; candidate may help shape department strategy for PKDM projects in a fast-paced environment.

Qualifications

• Doctorate degree PhD, PharmD or MD, or Master’s with 3 years of related experience, or Bachelor’s with 5 years of related experience.
• PhD or MS in immunology, cell biology, biochemistry, biophysics, or equivalent.
• 2+ years of protein therapeutics drug discovery and development experience with PK/PD understanding.
• Expertise in protein biochemistry and/or cell biology techniques, including reagent preparation, assay development, optimization and troubleshooting.
• Experience translating biochemical/biophysical observations into cellular/animal models with mechanistic insights.
• Excellent communication and interpersonal skills; ability to work in a fast-paced environment.

Responsibilities

• Design and execute biological and/or biophysical experiments to understand ADME properties of large molecule therapeutics for drug discovery and early development.
• Lab-based role emphasizing assay/technology development for defining in vivo clearance and biodistribution mechanisms.
• Interpret data and communicate results to project team representatives; maintain electronic lab notebook.
• May develop and execute department strategy for PKDM project teams as a PKDM representative.

Skills

ADME biology

Biophysical assays

Data interpretation

Communication

Education

PhD

PharmD

MD

Master's + 3 yrs

Bachelor's + 5 yrs

Tools

ELN

Job description

Career Category Research Job Description

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award‑winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist - PKDM-BA

What you will do

The responsibilities of the successful candidate will be to design and execute biological and/or biophysical experiments to understand the ADME properties of large molecule therapeutics (and non-traditional small molecule therapies) in support of both drug discovery and early development programs. This is a lab-based role, with an emphasis on assay/technology development for the purposes of defining mechanisms of in vivo clearance and/or biodistribution processes. This role requires an understanding of preclinical ADME and bioanalytical techniques and an individual that can work collaboratively in a fast-paced work environment. Other responsibilities include data interpretation and communication of results to project team representatives and electronic laboratory notebook keeping of results. The candidate may also be responsible for developing and executing department strategy for drug candidate teams as a PKDM project representative.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications.

Basic Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] OR Master’s degree and 3 years of related experience OR Bachelor’s degree and 5 years of related experience

Preferred Qualifications

• PhD or MS in immunology, cell biology, biochemistry, biophysics, or equivalent.
• 2+ years of protein therapeutics drug discovery and development experience in biotech industry, basic understanding of protein therapeutics pharmacokinetics. Expertise, and a strong interest in evaluating protein-protein interactions using modern biophysical analytic techniques.
• Expertise in protein biochemistry and/or cell biology techniques, including reagent preparation, assay development, optimization and troubleshooting.
• Experience translating biochemical and biophysical observations and phenomena into relevant cellular and animal-based models with mechanistic insights is desirable.
• Excellent communication and interpersonal skills and the ability and interest to learn and deliver results in a fast-paced, demanding environment.

What you can expect from us

From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan
• Stock‑based long‑term incentives
• Award‑winning time‑off plans
• Flexible work models where possible.

Sponsorship

Sponsorship for this role is not guaranteed.

Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Equal Opportunity

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Salary Range 143,820.85USD -194,581.15 USD

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. For more information, visit www.amgen.com and follow us on www.twitter.com/amgen