Biophysics Scientist

Amgen SA; Thousand Oaks, Northern (CA, KY); Hybrid; USD 120,000 - 160,000; Full time

Job summary

Amgen in Thousand Oaks, CA is seeking a Biophysics Scientist to join a team discovering innovative biologics. You will apply state-of-the-art SPR to characterize binding affinities and support drug discovery while collaborating with biology, chemistry, and computational groups.

The role emphasizes rigorous data generation and clear communication of results, with opportunities to work on ML/AI modeling to improve molecular attributes and cross-functional collaboration.

Qualifications

• Knowledge in protein chemistry, cell biology, biophysics and binding analysis using SPR.
• Excellent laboratory work ethic and communication skills.
• Flexibility, ingenuity, problem-solving and multi-tasking ability.
• Hands-on lab automation experience with Bravo and Hamilton.
• Experience bridging experiments with computational modeling and ML.

Responsibilities

• Use SPR instruments to perform high-throughput binding affinity characterization on biologics.
• Determine cross-species selectivity and study mechanism of action related to binding.
• Generate and analyze data; communicate results clearly, orally and in writing.
• Collaborate with scientists across functions and with Computational Sciences for ML/AI models.

Skills

SPR binding analysis

Biophysics

Protein chemistry

Data analysis

Cross-functional collaboration

Education

PhD

PharmD

MD

Master's degree + 3 years experience

Bachelor's degree + 5 years experience

Tools

Bravo automation

Hamilton automation

ML/AI modeling

Job description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Biophysics Scientist

What you will do

Let’s do this. Let’s change the world. In this vital role you will be a member of a team involved in the discovery of innovative biological therapeutics. This team is applying state-of-art experimental technologies that are transforming the way we discover and develop new medicines for our patients.

Key Responsibilities:

• Using state-of-the- art Surface Plasmon Resonance (SPR) instruments, you will implement and execute high throughput binding affinity characterization on biologics from generative biology, which plays a critical role in Amgen’s drug discovery pipeline.
• In addition to affinity characterization, you will be expected to determine cross-species selectivity and implement experiments to study mechanism of action when related to binding interactions.
• You should be meticulous and proficient in generating and analyzing scientific data, and will be expected to communicate the results clearly, both orally and in written form.
• You will be able to work collaboratively with other scientists, within and across functions.
• You will be expected to interface with our Computational Sciences Group to develop ML/AI models that improve molecular attributes, such as binding activities.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Scientist we seek is a researcher with these qualifications.

Basic Qualifications:

Doctorate degree PhD

OR

PharmD

OR

MD [and relevant post-doc where applicable]

OR

Master’s degree and 3 years of scientific experience

OR

Bachelor’s degree and 5 years of scientific experience

Preferred Qualifications:

• Knowledge in protein chemistry, cell biology, biophysics, and experience in binding analysis using Surface Plasmon Resonance (SPR).
• Demonstrated excellent laboratory working ethic and skills, excellent communication skills (both written and oral).
• Demonstrated flexibility, ingenuity, and problem-solving capability, as well as a strong ability to multi-task.
• Hands-on experience in lab automation, such as Bravo, Hamilton, biochemical and cellular assays using advanced instruments.
• Knowledge and hands-on experience in membrane protein generation and characterization are highly desirable.
• Demonstrated capabilities of bridging experimentation with computational modeling and ML activities.

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.