Senior Scientist - PKDM-BA

Amgen SA; South San Francisco (CA); On-site; USD 150,000 - 210,000; Full time

Job summary

Amgen in South San Francisco seeks a Senior Scientist to advance PKDM programs by designing and executing biological and biophysical experiments to characterize ADME of large molecules in discovery and early development.

The role emphasizes lab-based assay development, data interpretation, collaboration with project teams, and potential leadership in department strategy for PKDM project teams.

Qualifications

• PhD, MS, or PhD/MD in immunology, cell biology, biochemistry, biophysics, or equivalent.
• 2+ years of protein therapeutics drug discovery and development experience in biotech.
• Strong interest in evaluating protein–protein interactions using modern biophysical analytic techniques.
• Expertise in protein biochemistry and/or cell biology techniques including reagent preparation, assay development, optimization, and troubleshooting.
• Experience translating biochemical/biophysical observations into cellular and animal models with mechanistic insights.
• Excellent communication and interpersonal skills in a fast-paced environment.

Responsibilities

• Design and execute biological and/or biophysical experiments to understand ADME properties of large molecule therapeutics.
• Lab-based role with emphasis on assay/technology development for in vivo clearance and biodistribution mechanisms.
• Data interpretation and communication of results to project teams; electronic notebook keeping.
• Possibility to develop and execute department strategy for PKDM project teams.

Skills

Protein biochemistry

Cell biology

Biophysics

Protein interactions analysis

Assay development

Reagent preparation

Data interpretation

Communication skills

Education

PhD/MD/MS/PharmD

Master’s degree with 3+ years experience

Bachelor’s degree with 5+ years experience

Job description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist - PKDM-BA

What you will do

Let’s do this. Let’s change the world. The responsibilities of the successful candidate will be to design and execute biological and/or biophysical experiments to understand the ADME properties of large molecule therapeutics (and non-traditional small molecule therapies) in support of both drug discovery and early development programs.

This is a lab-based role, with an emphasis on assay/technology development for the purposes of defining mechanisms of in vivo clearance and/or biodistribution processes. This role requires an understanding of preclinical ADME and bioanalytical techniques and an individual that can work collaboratively in a fast-paced work environment.

Other responsibilities include data interpretation and communication of results to project team representatives and electronic laboratory notebook keeping of results. The candidate may also be responsible for developing and executing department strategy for drug candidate teams as a PKDM project representative.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]

OR

Master’s degree and 3 years of related experience

OR

Bachelor’s degree and 5 years of related experience

Preferred Qualifications:

• PhD or MS in immunology, cell biology, biochemistry, biophysics, or equivalent.

• 2+ years of protein therapeutics drug discovery and development experience in biotech industry, basic understanding of protein therapeutics pharmacokinetics.

• Expertise, and a strong interest in evaluating protein-protein interactions using modern biophysical analytic techniques.

• Expertise in protein biochemistry and/or cell biology techniques, including reagent preparation, assay development, optimization and troubleshooting.

• Experience translating biochemical and biophysical observations and phenomena into relevant cellular and animal-based models with mechanistic insights is desirable.

• Excellent communication and interpersonal skills and the ability and interest to learn and deliver results in a fast-paced, demanding environment.

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans

• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.