Senior Scientist, Oncology Discovery Biology

Lensa; Cambridge (MA); On-site; USD 111,000 - 170,000; Full time

Job summary

A leading company focused on revolutionary cancer therapeutics is seeking a Senior Scientist in Oncology Discovery Biology in Cambridge. The role involves evaluating novel therapeutic targets and leading innovative research efforts within a collaborative team environment. Candidates should have a strong background in immuno-oncology, proven problem-solving skills, and experience in assay development.

Qualifications

• Requires Ph.D. with 2+ years experience in oncology.
• Track record in immuno-oncology and biologics drug discovery.
• Strong publication record is essential.

Responsibilities

• Proposes and evaluates target ideas in Cancer Immunology.
• Executes experiments in tissue culture and flow cytometry.
• Collaborates with cross-functional teams on drug development.

Skills

Immuno-oncology

Flow cytometry

Problem-solving

Education

Ph.D. or equivalent advanced degree in the Life Sciences

Master's Degree

Bachelor's Degree

Tools

CRISPR

RNAi

High-throughput assays

Job description

Senior Scientist, Oncology Discovery Biology

Senior Scientist, Oncology Discovery Biology

1 day ago Be among the first 25 applicants

Lensa partners with DirectEmployers to promote this job for Bristol-Myers Squibb.

Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Responsibilities

In the role as a Senior Scientist within the Cancer Immunology team, the ideal candidate:

• Proposes and evaluates new target ideas in the Cancer Immunology space.
• Uses current and innovate new techniques for identification and selection of T cell engager (TCE) lead drug candidates.
• Executes experiments independently, troubleshoot as needed, interpret, and discuss data.
• Performs laboratory work related but not limited to tissue culture, multi-parametric flow cytometry, western blot, immune cell culture using activation/expansion/exhaustion assays, proliferation and tumor killing assays, 2D/3D co-culture activity assays, ELISA, Luminex, processing of DNA/RNA/protein.
• Accurate and detailed record-keeping.
• Presents data in project meetings and department meetings.
• Collaborates with rest of biology team members as well as other functional area leads e.g. protein purification, in vivo pharmacology, DMPK, informatics.
• Utilizes excellent communication and interpersonal skills.
  
  

Basic Qualifications

• Bachelor's Degree
• 7+ years of academic and / or industry experience
  
  

Or

• Master's Degree
• 5+ years of academic and / or industry experience
  
  

Or

• Ph.D. or equivalent advanced degree in the Life Sciences
• 2+ of academic and / or industry experience
  
  

Preferred Qualifications

• PhD with 2-4 years of experience.
• Experience and track record in immuno-oncology, immunology, or biologics drug discovery.
• Good understanding of vascular, stromal biology or T cell biology
• Experienced in the design, development and optimization of high-throughput cell-based assays for TCE activity.
• Proficient with primary cell culture and cancer cell line culture.
• Experience with expression modulation tools (overexpression, CRISPRs, RNAi, etc.).
• Extensive knowledge of flow cytometry (BD, Cytek Aurora, iQue).
• Experience with automation systems (TECAN, Integra, etc.).
• Experience with imaging platforms (Incucyte, Opera Phenix etc.).
• Familiar with data mining with published data platforms (DepMap, TCGA, GTEx, GEO, etc.)
• Strong problem-solving skills and understanding of relevant scientific principles.
• Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work.
• Ability to summarize and interpret scientific data in a clear, concise, and accurate manner.
• Understand basics to use generative AI to accelerate workflow. Knowledge in scientific coding languages (R, python, etc.) preferred.
• Strong publication record.
  
  

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients' lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

Responsibilities

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail] . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Company: Bristol-Myers Squibb

Req Number: R1592333

Updated: 2025-06-23 04:09:53.878 UTC

Location: Cambridge Crossing-MA

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

If you have questions about this posting, please contact [e-mail]

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

• Industries

  IT Services and IT Consulting

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