SENIOR SCIENTIST- REMOTE

ZipRecruiter; Groton (MA); Remote; USD 90,000 - 130,000; Full time

Job summary

A leading company in drug discovery is seeking a Senior Scientist in Biotransformation to join their team focused on small molecule drug discovery. You will analyze HRMS data to aid in understanding human drug metabolism, participating in cutting-edge research with significant therapeutic impact. This long-term role offers opportunities for scientific growth and collaboration within a dynamic team.

Qualifications

• Strong understanding of human drug metabolism and common metabolite structures.
• Demonstrated experience analyzing HRMS data including fragmentation.
• Proficiency in at least one programming language like Python or R.

Responsibilities

• Analyze high-resolution mass spectrometry data for structural elucidation.
• Collaborate with computational team to develop models supporting drug discovery.
• Contribute to internal discussions and presentations of data insights.

Skills

Human drug metabolism enzymes

Statistical principles

Data visualization tools

Analytical problem-solving

Education

PhD in Pharmaceutical Sciences, Chemistry, or Biochemistry

Tools

Excel

Spotfire

Tableau

JMP

Python

R

Job description

Job DescriptionJob Description

ROLE SENIOR SCIENTIST - Biotransformation

INDUSTRY Life Sciences

DURATION CONTRACT

LOCATION REMOTE reporting to Groton, CT 06340

INTERVIEW pre-qualifying MS TEAMS conversation

SUMMARY

Our client in Groton, CT, a leader in drug discovery and development, is seeking a Senior Scientist – Biotransformation to join their Pharmacokinetics, Dynamics, and Metabolism (PDM) team focused on small molecule drug discovery. In this role, you will support and guide the understanding of human drug metabolism through curation and interpretation of large-scale experimental metabolite ID data to drive predictive modeling efforts to maximize the value of the curated data. This is a long-term engagement offering the opportunity to contribute to cutting-edge research with real-world therapeutic impact.
This is an 18 month engagement.

RESPONSIBILITIES

• Analyze high-resolution mass spectrometry data (HRMS), including MS2 fragmentation for small molecule structural elucidation.
• Interpret metabolic pathways using knowledge of human drug-metabolizing enzymes and common metabolite types.
• Collaborate with computational ADME staff to develop and apply computational models to support biotransformation research in small molecule drug discovery.
• Leverage spreadsheets and/or BI tools (e.g., Excel, Spotfire, Tableau, JMP) for data visualization and analysis.
• Apply statistical methods to derive insights from complex datasets.
• Contribute to internal discussions and presentations of data insights and recommendations.

REQUIRED

• PhD in a relevant field (e.g., Pharmaceutical Sciences, Chemistry, Biochemistry) or MS with 2+ years of relevant industry experience.
• Strong understanding of:
• Human drug metabolism enzymes
• Common metabolite structures
• General organic chemistry
• Experimental systems for assaying metabolism
• Demonstrated experience analyzing HRMS data, including MS2 fragmentation patterns.
• Keen interest in computational approaches and data-driven science.
• Proficiency with data visualization tools (Excel, Spotfire, Tableau, JMP).
• Solid foundation in statistical principles (through coursework or practical application).
• Strong analytical and problem-solving skills.

• 
  
  • Experience with automated analysis of HPLC-HRMS or HPLC-UV-HRMS datasets.
  • Familiarity with HPLC-UV data analysis.
  • Proficiency in at least one programming (e.g., Python, R).
  • Be part of a collaborative and innovative team at the intersection of drug metabolism and data science.
  • Contribute directly to projects that advance therapeutic development.
  • Enjoy opportunities for scientific growth and long-term professional engagement.

Company DescriptionNexPro Technologies offers robust, responsive and value-driven IT consulting and placement services.Company DescriptionNexPro Technologies offers robust, responsive and value-driven IT consulting and placement services.