Senior Scientist - Oligo Bioinformatics

Biopharma Careers; Billerica (MA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Health insurance

Paid time off

Retirement contributions

Job summary

EMD Serono in Billerica, MA, seeks a Senior Scientist in Oligonucleotide Bioinformatics to lead computational design for siRNA/ASO pipelines. You’ll sit at the intersection of computation, chemistry, and drug discovery, shaping programs from target ID to lead optimization.

A fast-paced, collaborative lab environment awaits your algorithms guiding experiments. PhD in a relevant field with 3+ years in oligonucleotide work is required.

Qualifications

• PhD in chemistry, chemical engineering or related science field.
• At least 3+ years in the oligonucleotide field.

Responsibilities

• Design and optimize siRNA/ASO sequences using bioinformatics.
• Analyze gene expression to identify targets for development.
• Collaborate with chemists and biologists to integrate workflows.
• Perform transcriptome-wide off-target prediction and annotation.
• Develop pipelines for mapping coordinates and homology assessments.
• Analyze HTS data to identify SAR.

Skills

Oligonucleotide bioinformatics

RNA-Seq analysis

Bioinformatics tools

Education

PhD in Chemistry/Engineering/Science

Tools

BLAST

RNAfold

siRNA design tools

Job description

Work Your Magic with us! Start your next chapter and join EMD Serono.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role:

Are you passionate about translating complex genomic data into life-changing RNA therapeutics? Our Oligonucleotide Therapeutics Group (DDTech) at EMD Serono in Billerica, MA, is expanding, and we are looking for a Senior Scientist in Oligo Bioinformatics to lead the computational design and optimization of our next-generation siRNA and ASO pipelines.

In this role, you will sit at the crucial intersection of computational biology, chemistry, and drug discovery, directly shaping therapeutic programs from target identification through lead optimization. If you thrive in a fast-paced, highly collaborative environment where your algorithms directly inform lab experiments, we want to hear from you.

Responsibilities:

• Utilize Bioinformatics platforms to design, evaluate and optimize siRNA and ASO sequences for targeted gene silencing
• Analyze gene expression data to identify suitable targets for siRNA/ASO development
• Work closely with chemists and biologists to integrate bioinformatics approaches into experimental workflow
• Perform transcriptome wide off-target prediction and annotation
• Develop pipelines that determine mapping coordinates and homology of oligonucleotides to genomes and transcriptomes
• Analyze High through put screening datasets and identify SAR

Who You Are:

Minimum Qualifications:

• PhD in Chemistry, Chemical Engineering or other Science or Engineering discipline
• 3+ years of dedicated experience within the Oligonucleotide field

Preferred Qualifications:

• Proficient in Bioinformatics tools and software (e.g. BLAST, Ensemb. RNA fold, siRNA design tools)
• Experience with common human genetics resources and techniques
• E xperience with analyzing large genomic and transcriptomic datasets including RNA seq, Single cell RNA seq, splice isoforms and variant database
• H ighly collaborative and strong problem-solving ability
• S trong organizational skills and ability to manage multiple experiments or project priorities in a fast-paced research environment
• E xcellent written and verbal communication skills and strong scientific curiosity and innovation mindset
• A bility to work effectively in a collaborative, cross-functional team environment

Pay Range for this position:

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites.

What we offer:

We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!