Senior Scientist - Oligo Bioinformatics

EMD Serono, Inc.; Billerica (MA); On-site; USD 113,000 - 169,000; Full time

Benefits offered by this job

Health insurance

PTO

Retirement contributions

Performance bonuses

Job summary

EMD Serono, Inc. in Billerica, MA, seeks a Senior Scientist in Oligonucleotide Bioinformatics to lead computational design and optimization of siRNA and ASO pipelines. You will sit at the intersection of computational biology, chemistry, and drug discovery, shaping programs from target ID through lead optimization.

The role demands fast-paced collaboration with chemists and biologists, delivering algorithms that inform lab experiments and drive therapeutic development.

Qualifications

• PhD in Chemistry, Chemical Engineering or related field.
• Minimum 3+ years in the Oligonucleotide field.
• Strong background in computational biology and genomics.

Responsibilities

• Design, evaluate and optimize siRNA and ASO sequences.
• Analyze gene expression data to identify targets for siRNA/ASO development.
• Integrate bioinformatics with experimental workflows in chemistry and biology.
• Perform transcriptome-wide off-target prediction and annotation.
• Develop pipelines for mapping coordinates and homology to genomes/transcriptomes.
• Analyze high-throughput screening datasets and identify SAR.

Skills

Bioinformatics

RNA-seq analysis

Collaborative work

Problem solving

Education

PhD in Chemistry / Chemical Engineering or related

Tools

BLAST

RNAfold

siRNA design tools

Job description

Work Your Magic with us! Start your next chapter and join EMD Serono.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role

Are you passionate about translating complex genomic data into life-changing RNA therapeutics? Our Oligonucleotide Therapeutics Group (DDTech) at EMD Serono in Billerica, MA, is expanding, and we are looking for a Senior Scientist in Oligo Bioinformatics to lead the computational design and optimization of our next-generation siRNA and ASO pipelines.

In this role, you will sit at the crucial intersection of computational biology, chemistry, and drug discovery—directly shaping therapeutic programs from target identification through lead optimization. If you thrive in a fast-paced, highly collaborative environment where your algorithms directly inform lab experiments, we want to hear from you.

Responsibilities

• Utilize Bioinformatics platforms to design, evaluate and optimize siRNA and ASO sequences for targeted gene silencing
• Analyze gene expression data to identify suitable targets for siRNA/ASO development
• Work closely with chemists and biologists to integrate bioinformatics approaches into experimental workflow
• Perform transcriptome wide off-target prediction and annotation
• Develop pipelines that determine mapping coordinates and homology of oligonucleotides to genomes and transcriptomes
• Analyze High through put screening datasets and identify SAR

Who You Are

Minimum Qualifications:

• PhD in Chemistry, Chemical Engineering or other Science or Engineering discipline
• 3+ years of dedicated experience within the Oligonucleotide field

Preferred Qualifications

• Proficient in Bioinformatics tools and software (e.g. BLAST, Ensemb. RNA fold, siRNA design tools)
• Experience with common human genetics resources and techniques
• Experience with analyzing large genomic and transcriptomic datasets including RNA seq, Single cell RNA seq, splice isoforms and variant database
• Highly collaborative and strong problem-solving ability
• Strong organizational skills and ability to manage multiple experiments or project priorities in a fast-paced research environment
• Excellent written and verbal communication skills and strong scientific curiosity and innovation mindset
• Ability to work effectively in a collaborative, cross-functional team environment

Pay Range for this position:

Pay Range for this position: $112,800 - $169,200

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites.

RSREMD

What we offer:

We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!