Senior Scientist: Nuclear Receptors & Chemical Probes

St. Jude Children's Research Hospital, Inc.

Memphis (TN)

On-site

USD 104,000 - 186,000

Full time

14 days+

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Job summary

St. Jude Children's Research Hospital, Inc. is seeking a Scientist or Senior Scientist to lead research on novel chemical probes targeting nuclear receptors, with emphasis on PXR and CAR.

You will independently design studies, generate datasets, and collaborate with biologists, chemists, and structural biologists to advance projects toward publication and impact. The role requires a strong track record in cell and molecular biology, chemical biology, and small-molecule action studies, plus the

Qualifications

PhD preferred with strong publication record.
Bachelor's degree required in a relevant scientific field.
Experience with cell/molecular biology and chemical biology is essential.

Responsibilities

Conduct experiments independently under PI guidance.
Design and optimize protocols in cell, molecular and chemical biology.
Characterize mechanisms of action for small molecules and degraders.
Collaborate with structural biologists and medicinal chemists.
Prepare manuscripts and present findings at meetings.

Skills

Cell biology

Molecular biology

Chemical biology

Publication track record

Education

Bachelor's degree in relevant scientific field

PhD in cell biology / molecular biology / chemical biology or related field

Tools

DNA cloning

RNA analysis

Western blotting

Protein interactions

Proteomics

Structural biology basics

Medicinal chemistry concepts

Murine studies

Job description

St. Jude Children's Research Hospital, Inc. is seeking a Scientist or Senior Scientist to lead research on novel chemical probes targeting nuclear receptors, with emphasis on PXR and CAR.

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