Senior Scientist — Nuclear Receptors & Chemical Biology

St. Jude Children's Research Hospital; Memphis (TN); On-site; USD 86,000 - 186,000; Full time

Job summary

St. Jude Children's Research Hospital in Memphis, TN seeks a collaborative Scientist or Senior Scientist to lead research on novel chemical probes targeting nuclear receptors PXR and CAR. You will design studies, generate high‑quality data, and collaborate with structural biologists and medicinal chemists to advance projects.

The role includes leading manuscript writing and multidisciplinary integration. The lab emphasizes multidisciplinary approaches across cellular, molecular, and chemical

Qualifications

• Bachelor’s degree in a relevant scientific area is required.
• A PhD in cell biology, molecular biology, chemical biology, pharmacology, or a related field, with productive postdoctoral experience, is strongly preferred
• Ten (10) years relevant work experience for Sr. Scientist; five (5) years with PhD; eight (8) years with a Master’s

Responsibilities

• Conducts experiments/projects independently under overall direction of the PI or senior scientist.
• Develops new research protocols, techniques and procedures.
• Identifies experimental data pertinent to the analysis problem and ensures data quality.
• May publish as co-author and draft sections of manuscripts; present research at meetings.
• Trains and oversees lab personnel; supports lab operations and equipment maintenance.
• Maintains regular and predictable attendance.

Skills

Cell biology

Molecular biology

Chemical biology

Small molecules

Structural biology

Medicinal chemistry

Gene expression analysis

Protein interactions

Education

Bachelor's degree in a relevant scientific area

PhD in cell biology, molecular biology, chemical biology, pharmacology or related field (preferred)

Tools

Western blotting

Mass spectrometry

Protein assays

Job description

St. Jude Children's Research Hospital in Memphis, TN seeks a collaborative Scientist or Senior Scientist to lead research on novel chemical probes targeting nuclear receptors PXR and CAR. You will design studies, generate high‑quality data, and collaborate with structural biologists and medicinal chemists to advance projects.

The role includes leading manuscript writing and multidisciplinary integration. The lab emphasizes multidisciplinary approaches across cellular, molecular, and chemical