Senior Scientist, Multiomics Discovery

Scorpion Therapeutics; Spring House (PA); On-site; USD 120,000 - 180,000; Full time

Job summary

Johnson & Johnson is seeking a Senior Scientist in Multiomics Discovery based in Spring House, PA. The role focuses on deriving mechanistic insights from spatial omics-based phenotypic assays to support immunology, neuroscience, and oncology research.

The position emphasizes designing genetic libraries for CRISPR and reporter systems, developing advanced cellular models, and collaborating with computational teams to analyze data, driving innovation in assay development and complex disease

Qualifications

• PhD in Biological Sciences with 3+ years biotech/industry experience.
• Proven track record in genetic perturbation and complex model systems.
• Experience with data visualization and high-impact publications.

Responsibilities

• Design genetic libraries for CRISPR and reporter systems.
• Develop assay platforms including high-content imaging and MPRA.
• Engineer advanced cellular models (immune cells, organoids, co-culture).
• Collaborate with computational teams for data analysis.

Skills

Genetic perturbation

Massively parallel genetic screens

Data visualization

High-content imaging

CRISPR strategies

Interpreter of complex biological data

R

Python

Education

PhD in Biological Sciences

Tools

CRISPR

MPRA

Next-generation sequencing

Job description

Role

Senior Scientist in Multiomics Discovery at Johnson & Johnson, focused on developing mechanistic insights from spatial omics-based phenotypic assays to support immunology, neuroscience, and oncology research.

Responsibilities

Responsibilities include designing genetic libraries for CRISPR and reporter systems, developing complex assay platforms such as high-content imaging and MPRA, engineering advanced cellular models including immune cells, organoids, and co-culture systems, and collaborating with computational teams for data analysis. The role emphasizes innovation in assay development, troubleshooting technical challenges, and expanding cellular and genomic methodologies.

Requirements

PhD in relevant biological sciences, with 3+ years biotech or industry experience or equivalent postdoctoral/academic expertise; proven track record in genetic perturbation, high-impact publications, and complex model systems; expertise in massively parallel genetic screens, assay optimization, and data visualization; excellent communication skills.

Preferred skills

Proficiency in R/Python, experience with in vivo screens, histology, pathology, and next-generation sequencing.

Location

The position is based in Spring House, PA, with a focus on advancing spatial omics technologies and cellular screening platforms to enable discovery in complex disease biology.