Senior Scientist, In Vivo CAR-T

Legend Biotech; Philadelphia (Philadelphia County); On-site; USD 80,000 - 130,000; Full time

Job summary

An innovative firm dedicated to pioneering cell-based therapies is seeking a Senior Scientist to join their dynamic R&D team in Philadelphia. This role involves advancing in vivo CAR-T cell therapy through extensive research in virology and molecular biology. The successful candidate will play a critical role in optimizing cell-based immunoassays, designing experiments, and collaborating across teams to translate findings into clinical applications. If you are passionate about improving patient outcomes and thrive in a fast-paced environment, this opportunity is perfect for you.

Qualifications

• PhD in virology, immunology, or cell biology required.
• 2-3 years industry experience in cell and gene therapy preferred.

Responsibilities

• Develop cell and gene therapy platform and optimize immunoassays.
• Independently design and execute experiments, documenting results.

Skills

Virology

Molecular Biology

CAR-T Cell Therapy

Flow Cytometry

Cell Culture

Education

PhD in Virology

Master's in Immunology or Cell Biology

Tools

ELISA

Cytotoxic Assays

Multi-color Flow Cytometry

Job description

Legend Biotech is seeking a Senior Scientist, In Vivo CAR-T as part of the R&D team based in Philadelphia, PA.

Role Overview

Legend Biotechnology is at the forefront of developing innovative cell-based therapies. We are seeking an experienced and dynamic senior scientist to support our in vivo CAR-T cell therapy program. If you're passionate about advancing groundbreaking treatments and have a strong background in cellular immunotherapy, this role is for you.

The successful candidate should possess extensive knowledge and research experience in virology, molecular biology, and CAR-T cell therapy. The candidate will contribute to in vivo cell therapy platform and pipeline development through lentivirus preparation, ex vivo and in vitro function assays to evaluate product potency and safety. 2-3 years biotech or pharmaceutical industry or postdoctoral experience is required.

You will collaborate with team members and cross-functional teams, including research, development, and manufacturing, to drive the successful translation of preclinical findings into clinical applications. Your expertise will be critical in advancing our mission to improve patient outcomes.

The candidate needs to demonstrate the ability to deliver scientific results with integrity and within timelines, value collaboration and teamwork, and provide expertise and team support in a fast-paced environment.

Key Responsibilities

1. Develop cell and gene therapy platform and optimize cell-based immunoassays, including vector design, virus packaging and titering, immune cell isolation and expansion, multi-color flow cytometry, ELISA, cytotoxic assays, VCN analysis.
2. Plan experiments to test different designs to deliver reliable and consistent data.
3. Independently design and execute experiments, document and interpret scientific results, and present data within research and cross-functional teams.
4. Support projects from early research to clinical stage (preferred).
5. Stay updated on industry developments and new technologies/platforms in the field.
6. Perform lab support work as needed.

Requirements

• PhD in virology, immunology, cell biology, or a master's with extensive experience.
• >2 years' post-graduate experience in virology and human immunology; 2-3 years industry experience in cell and gene therapy (preferred).
• Knowledge of molecular biology, T cell culture, flow cytometry, and animal models (preferred).

Legend Biotech is an equal opportunity employer committed to diversity and inclusion. It maintains a drug-free workplace.