Senior Scientist, In Vivo CAR-T

Mote Marine Laboratory; Philadelphia (Philadelphia County); On-site; USD 90,000 - 130,000; Full time

Job summary

A leading biotechnology company in Philadelphia is looking for a Senior Scientist to advance their in vivo CAR-T cell therapy program. As part of the R&D team, you will leverage your expertise in virology and molecular biology to develop innovative therapies and enhance patient outcomes. This dynamic role requires collaboration across various teams, underscoring the importance of scientific integrity and teamwork in a fast-paced environment.

Qualifications

• Experience in virology and human immunology (2+ years).
• 2-3 years of industry experience in cell and gene therapy preferred.
• Knowledge of T cell culture and assay development recommended.

Responsibilities

• Develop and optimize cell-based immunoassays and therapies.
• Independently design and execute experiments, analyze data.
• Support project from early research stages to clinical applications.

Skills

Virology

Molecular Biology

Cellular Immunotherapy

Flow Cytometry

Animal Models

Education

PhD in Virology/Immunology/Cell Biology

Master's with Extensive Experience

Job description

Legend Biotech is seeking a Senior Scientist, In Vivo CAR-T as part of the R&D team based in Philadelphia, PA.
Role Overview

Legend Biotechnology is at the forefront of developing innovative cell-based therapies. We are seeking an experienced and dynamic senior scientist to support our in vivo CAR-T cell therapy program. If you're passionate about advancing groundbreaking treatments and have a strong background in cellular immunotherapy, this role is for you.

The successful candidate should possess extensive knowledge and research experience in virology, molecular biology, CAR-T cell therapy. The candidate will be able to contribute to in vivo cell therapy platform and pipeline development through lentivirus preparation, ex vivo and in vitro function assays to evaluate product potency and safety. 2-3 year biotech or pharmaceutical industry or postdoc experience is required.

You will collaborate with team members and cross-functional teams, including research, development, and manufacturing, to drive the successful translation of preclinical findings into clinical applications. Your expertise will be critical in advancing our mission to improve patient outcomes.

The candidate needs to demonstrate the ability of delivering scientific results with integrity and timeline, show the value of collaboration and teamwork, and provide expertise and team support in a fast-paced environment.

Key Responsibilities

• Develop cell and gene therapy platform and optimize cell-based immunoassays, including vector design, virus packaging and titering, immune cell isolation and expansion, multi-color flow cytometry, ELISA, cytotoxic assays, VCN analysis.
• Plan experiment to test different designs to deliver reliable and consistent data
• Independently design and execute experiments, document and interpret scientific results, present the data within research team and cross-functional teams
• Experience to support project from early research to clinical stage is a plus
• Stay alert to industry development, good sense of new tech/platform in the field
• Lab support work

Requirements

• PhD in virology/Immunology/cell biology, or master with extensive experience.
• >2 years' post-graduate experience in virology and human immunology, 2-3 years of industry experience in cell and gene therapy is preferred.
• Knowledge of molecular biology, T cell culture, flow cytometry, and animal model is preferred.

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Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.