Senior Scientist II, Computational Chemistry

Scorpion Therapeutics; California (MO); On-site; USD 150,000 - 210,000; Full time

Job summary

Scorpion Therapeutics seeks a Senior Scientist II in Computational Chemistry to lead drug discovery programs focusing on RAS-addicted cancers.

You will design and execute computational strategies for hit identification and lead optimization, integrate SAR, structural biology, and ADME/PK data to inform compound prioritization, and develop virtual screening workflows across multidisciplinary teams.

Qualifications

• PhD in computational chemistry or related field.
• 5+ years industry experience with impactful contributions to drug discovery.
• Expertise in protein-ligand analysis, molecular modeling, MD simulations, QM calculations, and relevant software.

Responsibilities

• Design and execute computational strategies for hit identification and lead optimization.
• Integrate SAR, structural biology, and ADME/PK data to inform compound prioritization.
• Develop virtual screening workflows and evaluate advanced computational methods including physics-based modeling and AI/ML.

Skills

Protein-ligand analysis

Molecular modeling

MD simulations

QM calculations

Python

Bash

R

Education

PhD in Computational Chemistry

Tools

Python

Bash

R

Job description

Role: Senior Scientist II in Computational Chemistry leading drug discovery programs within a biopharma focused on RAS-addicted cancers.

Responsibilities

design and execute computational strategies for hit identification and lead optimization, integrate SAR, structural biology, and ADME/PK data to inform compound prioritization, develop virtual screening workflows, evaluate advanced computational methods including physics-based modeling and AI/ML, and collaborate across multidisciplinary teams to accelerate therapeutic development.

Requirements

• Ph.D. in computational chemistry or related field;
• 5+ years industry experience with impactful contributions to drug discovery, including publications and patents;
• expertise in protein-ligand analysis, molecular modeling, MD simulations, QM calculations, and relevant software;
• proficiency in programming languages such as Python, Bash, or R;
• excellent communication skills.

Preferred

• experience with challenging modalities like macrocycles, molecular glues, covalent ligands, HPC/cloud environments, and a strong publication record.

High-Value

• Oncology focus, RAS pathway, small molecules, early to late-stage (preclinical to clinical), computational drug design, interdisciplinary collaboration.

WorkSetup: Not specified.