Computational Chemistry Research Scientist (Computational Drug Design)

Scorpion Therapeutics; Boston (MA); Hybrid; USD 110,000 - 150,000; Full time

Job summary

Vertex's Drug Design group is seeking a Computational Chemist in Boston to identify hit/lead compounds and optimize them using molecular modeling, cheminformatics, data science, and AI.

You will apply computational methods to accelerate drug discovery, collaborate with cross-disciplinary teams, and help develop workflows while advancing computational capabilities in a hybrid or on-site Boston setting.

Qualifications

• Ph.D. in Computational Chemistry or related field.
• 0–3 years' experience in relevant roles.
• Expertise in structure-based drug design, AI tools, Python scripting, and familiarity with drug discovery concepts.

Responsibilities

• Apply computational methods to accelerate drug discovery.
• Collaborate with cross-disciplinary teams across Chemistry, Biology, and DMPK.
• Develop new workflows and pipelines for computational drug design.
• Enhance computational capabilities within the Drug Design group.

Skills

Structure-based drug design

AI tools

Python scripting

Drug discovery concepts

Education

Ph.D. in Computational Chemistry or related field

Tools

Molecular modeling software

Cheminformatics

AI frameworks

Job description

Role

Computational Chemist in Vertex's Drug Design group, focusing on hit/lead identification and optimization using molecular modeling, cheminformatics, data science, and AI.

Responsibilities

apply computational methods to accelerate drug discovery, collaborate with cross-disciplinary teams, develop new workflows, and enhance computational capabilities.

Qualifications

• Ph.D. in Computational Chemistry or related field;
• 0-3 years' experience;
• expertise in structure-based drug design, AI tools, Python scripting, and familiarity with drug discovery concepts.

High-Value

• focus on small molecules, biologics, or gene therapies; early to late-stage development;
• cross-functional collaboration with Chemistry, Biology, DMPK, Structural Biology;
• emphasis on innovative AI applications.

Work Setup

hybrid or on-site in Boston, with flexible work arrangements.