Senior Scientist II, Biologics Drug Product Development

BioSpace; Worcester (MA); On-site; USD 80,000 - 130,000; Full time

Job summary

An innovative firm is seeking a motivated Senior Scientist II to join their Biologics Drug Product Development team. This role involves characterizing cutting-edge biologics and developing new formulations, contributing to groundbreaking therapies. The ideal candidate will leverage their extensive experience in LCMS and protein analysis to support early-stage assessments and collaborate with cross-functional teams. With a focus on innovation and quality, this position offers a chance to make a significant impact in the field of biologics. Join a diverse and inclusive environment where your expertise will help shape the future of medicine.

Benefits

Health insurance

401(k)

Incentives

Qualifications

• 12+ years of experience in chemistry, chemical engineering, or biology.
• Deep understanding of LC/ESI-HR-MS techniques.

Responsibilities

• Characterize oligonucleotides and monoclonal antibodies via LCMS.
• Compile analytical data to support candidate screening.

Skills

LCMS characterization of oligonucleotides

Therapeutic antibodies analysis

Protein degradation mechanisms

Communication skills

Collaboration

Education

Bachelor’s degree in Chemistry

Master’s degree in Chemical Engineering

PhD in Biology

Tools

LC-MS instruments

Analytical techniques

Robotics

Job description

Senior Scientist II, Biologics Drug Product Development

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Senior Scientist II, Biologics Drug Product Development

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Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology, neuroscience, and eye care, as well as products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn, and TikTok.

Job Description

Background of Biologics Drug Product Development

The Biologics Drug Product Development (BIO DPD) team develops antibody drug conjugates (ADC) and other biologics using state-of-the-art formulation and analytical technologies. We generate valuable intellectual property through new formulation compositions, cost-effective manufacturing processes, and by preparing and defending CMC (Chemistry, Manufacturing, and Control) regulatory content.

We are seeking a highly motivated individual to support developability assessments for candidate molecules across various modalities. The candidate will support early-stage assessment of candidates from the Discovery pipeline, working closely with scientists from Discovery, Analytical, and Process R&D teams.

Your Responsibilities

• Characterize oligonucleotides (siRNA, mRNA), monoclonal antibodies, antibody-conjugates, novel multispecifics, and gene therapies via LCMS and physiochemical assessments.
• Utilize modern LC-MS instruments and techniques to understand degradation pathways and assess therapeutic biologics' quality.
• Evaluate stability (chemical & physical) of biologics under various solution conditions.
• Compile and assess analytical data to support candidate screening, including structure and impurity/variant characterization.
• Build and manage strategic alignments with stakeholders, revise workflows, and manage project timelines and resources.
• Operate within a matrix environment, aligning strategies and influencing stakeholders.
• Review data, prepare technical memos and reports.
• Mentor junior staff on troubleshooting equipment and experiments.
• Engage in cross-functional scientific initiatives, present data at conferences, and publish research findings.

Qualifications

• Bachelor’s degree with 12+ years, Master’s with 10+ years, or PhD with 4+ years in chemistry, chemical engineering, biology, or related fields.
• Experience in LCMS characterization of oligonucleotides and therapeutic antibodies.
• Knowledge of genetic medicines such as AAVs and LNPs is highly desirable.
• Deep understanding of LC/ESI-HR-MS techniques and protein degradation mechanisms.
• Experience with PTM and chemical modification analysis.
• Additional skills in robotics and protein analytical techniques are beneficial.
• Motivated, results-oriented, with excellent communication skills.
• Flexible, innovative, and collaborative team player.

Key Competencies

• Builds strong relationships, learns quickly, challenges the status quo, fosters innovation, and manages change effectively.

Additional Information

This is an on-site role at AbbVie Bioresearch Center in Worcester, MA, with compensation based on experience and location. Benefits include health insurance, 401(k), and incentives. AbbVie is an equal opportunity employer committed to diversity and inclusion.