Senior Scientist II, Biologics Drug Product Development

AbbVie; Worcester (MA); On-site; USD 80,000 - 130,000; Full time

Job summary

An innovative firm is seeking a Senior Scientist II to join their Biologics Drug Product Development team. This role involves the characterization of oligonucleotides and therapeutic antibodies using advanced LC-MS techniques. The successful candidate will collaborate with a global team, contribute to the development of cutting-edge biologics, and mentor junior staff. This position offers a unique opportunity to engage in impactful research while fostering innovation and collaboration in a dynamic environment. If you're motivated and results-oriented, this could be the perfect opportunity for you!

Qualifications

• 12+ years of experience in chemistry or related field.
• Experience with LCMS characterization of oligonucleotides and therapeutic antibodies.

Responsibilities

• Characterize oligonucleotides and monoclonal antibodies using LC-MS.
• Compile analytical data to support candidate screening.

Skills

LC-MS characterization

Analytical chemistry

Protein degradation analysis

Oligonucleotide analysis

Team collaboration

Project management

Education

Bachelor's Degree in Chemistry

Master's Degree in Chemical Engineering

PhD in Biology

Tools

LC-MS instruments

Robotics for protein analysis

Job description

Senior Scientist II, Biologics Drug Product Development

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Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

Background of Biologics Drug Product Development

The Biologics Drug Product Development (BIO DPD) team develops antibody drug conjugates (ADC) and other biologics by state-of-the-art formulation and analytical technologies. We create valuable intellectual property through new formulation compositions, cost effective manufacturing processes and prepare and defend CMC (Chemistry, Manufacturing and Control) regulatory content.

We are looking for a highly motivated person to support Developability assessments for candidate molecules across a range of modalities. The candidate will support early-stage assessment of candidates coming out of the Discovery pipeline. In this role, the candidate will be part of a global team and will work closely with scientists from multiple functional areas, including Discovery, Analytical, and Process R&D.

Your Responsibilities:

• Characterization of Oligonucleotides (siRNA, mRNA), monoclonal antibodies, Antibody-Conjugates (various payloads), novel multi-specifics, and gene therapies via LCMS and physiochemical assessments
• Employ modern LC-MS instruments and techniques to understand degradation pathways and gain insight into therapeutic biologic molecules and assess their quality
• Evaluate stability (chemical & physical) of biologics against solution conditions (pH, ionic strength, temperature, light, etc.) using standard analytical approaches
• Compile and assess analytical data regarding function and stability of molecules to support candidate screening in high throughput manner. Elucidate structure and impurity/variant characterization of protein and oligonucleotide-based drug materials.
• Build and manage strategic alignments with key stakeholders, revise and improve workflows, manage project timelines and resources. Contribute to CMC development paths for discovery projects, emphasizing collaboration and quality.
• Operate in a matrix team environment, align strategies, and influence stakeholders and teams as needed.
• Review data, document findings, and prepare technical memos and reports.
• Mentor junior staff on troubleshooting equipment and experimental issues.
• Engage in cross-functional teams, develop independent research ideas, present data at conferences, and prepare manuscripts or patents.

Qualifications

• Bachelor’s Degree with 12+ years, Masters with 10+ years, or PhD with 4+ years in chemistry, chemical engineering, biology, or related field
• At least 4 years’ experience in LCMS characterization of oligonucleotides and therapeutic antibodies
• Experience with genetic medicines like AAVs and LNPs is highly desired
• Deep understanding of LC/ESI-HR-MS analysis and protein degradation insights
• Knowledge of PTMs and chemical modifications affecting function and structure
• Robotics and protein analytical experience (SEC, IEX, HIC, CE) are beneficial
• Motivated, results-oriented, with excellent communication skills
• Flexible, innovative, and a strong team player

Key Competencies

• Builds strong relationships and collaborates effectively
• Learns quickly and adapts to change
• Raises standards and seeks continuous improvement
• Encourages innovation and experimentation

Level and compensation will be based on experience.