Senior Scientist II - AAV Gene Therapy Manufacturing

Novartis Group Companies; San Diego (CA); On-site; USD 99,000 - 183,000; Full time

Benefits offered by this job

Health benefits

401(k) plan with company match

Generous paid time off

Job summary

The Biologics Research Center at Novartis Biomedical Research in San Diego, CA is seeking a highly motivated scientist with recombinant AAV manufacturing expertise to join the Cell & Gene Therapy unit. The role supports early-stage AAV gene therapy by assessing downstream manufacturability and developing platform processes for novel capsids and cargo vectors.

Collaborating with Disease Areas, you will design experiments, prepare protocols and reports, and contribute to translating programs into

Qualifications

• Bachelor's or Master's degree in biochemistry, chemical engineering, bioengineering, or related technical field with 5+ years relevant experience.
• We will also consider recent PhD graduates (within last 2 years).
• Knowledge of downstream purification processes including affinity and ion-exchange chromatography with hands on experience with AKTA purification systems.
• Technical proficiency, creativity, and independent thoughts.
• Effective communication skills to convey scientific concepts to research scientists and cross-functional collaborators.
• Strong organization and problem-solving skills with attention to details.
• Ability to work in a fast-paced and matrix environment.

Responsibilities

• Perform different scales of purification process including depth filtration, ultracentrifugation, AKTA column chromatography, and TFF unit operations across multiple early-stage programs.
• Design and execute experiments to drive innovative technology and platform evaluation for next generation capsids.
• Perform experiment-related activities including buffer preparation, equipment maintenance, sample labelling and analytical sample submissions.
• Work collaboratively with upstream process development and analytical development teams.
• Engage collaboratively in operational and strategic discussions within a project core team.
• Assist knowledge transfer and work collaboratively with Technical Research & Development team to advance pipeline programs into clinical phases. Facilitate scientific and technical discussions during project translation, ensuring clarity and alignment of objectives across teams.
• Prepare protocols, reports, and provide high-quality data and electronic notebook documentation.
• Other related duties as assigned.

Job description

The Biologics Research Center at Novartis Biomedical Research in San Diego, CA is seeking a highly motivated scientist with recombinant AAV manufacturing expertise to join the Cell & Gene Therapy unit. The role supports early-stage AAV gene therapy by assessing downstream manufacturability and developing platform processes for novel capsids and cargo vectors.

Collaborating with Disease Areas, you will design experiments, prepare protocols and reports, and contribute to translating programs into