Senior Scientist I/II, In Vivo Pharmacology (Echocardiography) - CVM

Novartis Group Companies; Cambridge (MA); On-site; USD 85,000 - 159,000; Full time

Job summary

An innovative firm is seeking a highly motivated scientist specialized in echocardiography to join their in vivo pharmacology team. This role involves executing experiments in preclinical models of cardiovascular disease, employing advanced echocardiographic techniques to evaluate drug candidates. The ideal candidate will have a strong background in pharmacology or physiology, with hands-on experience in rodent models. Join a dedicated team focused on developing groundbreaking therapies for cardiometabolic diseases, contributing to life-saving advancements in medicine.

Qualifications

• 3-5+ years of experience in rodent echocardiography.
• Experience with animal models of heart failure and arrhythmia.

Responsibilities

• Design and execute echocardiographic experiments in animal models.
• Collaborate in a multidisciplinary team and present findings.

Skills

Echocardiography

Data Analysis

Collaboration

Drug Discovery

Communication Skills

Clinical Research

Analytical Thinking

Detail-Oriented

Education

Bachelor's in Pharmacology

Master's in Physiology

Tools

Microsoft Office

Statistical Software

Job description

Job Description Summary

We are seeking a highly motivated scientist specialized in echocardiography to join our in vivo pharmacology team in the Cardiovascular and Metabolic (CVM) Disease Area at the Novartis BioMedical Research (BR) facility located in Cambridge, MA. Cardiometabolic disease is the leading cause of death worldwide, taking an estimated 17.9 million lives each year. Our team is dedicated to the creation and development of innovative medicines to change this alarming statistic. We conceive, develop, validate, and employ pharmacological tools to evaluate the efficacy and safety of novel cardiometabolic drug candidates.

As an experienced and skilled lab-based echocardiographer, you will work both independently and collaboratively in an inter-disciplinary setting to execute experiments in preclinical models of cardiovascular disease. You will perform multi-mode echocardiography including strain by speckle tracking and Doppler imaging for heart systolic function and diastolic function. You will collect, analyze, and interpret echo images, and report cardiac structural and functional data in both written study reports and at team meetings. You will support drug discovery for heart failure and arrhythmia therapeutics by participating in pharmacodynamic/pharmacokinetic (PK/PD) and efficacy studies, while broadening your knowledge in the non-invasive imaging field.

#LI-Onsite
This position will be located at Cambridge and will not have the ability to be located remotely.

Job Description

Key responsibilities:

*Independently design, execute, analyze, and document in vivo echocardiographic experiments in heart failure and/or arrhythmia animal models.

*Employ good laboratory, data recording and data documentation practices.

*Establish new imaging techniques and approaches to support heart failure or arrhythmia studies.

*Support drug discovery projects with PK/PD studies.

*Collaborate effectively while working in a matrixed environment.

*Present results in lab and department meetings.

*Assist in the completion of research reports to support regulatory filings.

Role Requirements

*Bachelors or Masters in pharmacology, physiology, or other life sciences area

*3-5+ years of relevant experience in rodent echocardiography.

*Experience in handling, dosing, and phenotyping animal models of disease, ideally with an emphasis in heart failure, arrhythmia or cardiorenal disease, experience with non-rodent models would be a bonus

*Drug discovery experience desirable.

*Experience in working with a multidisciplinary team of scientists.

*Basic knowledge of statistics and experience with common statistical software for biomedical research.

*Proficiency with Microsoft Office (Word, Excel and PowerPoint).

*Strong written, oral and record keeping skills.

Novartis Compensation and Benefit Summary:.

The pay range for this position at commencement of employment is expected to be between $85,400- $158,600/year for Senior Scientist I and between $93,800-$174,00/year for Senior Scientist II; however, while salary ranges are effective from 1/1/25 through 12/31/25, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical,

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers who are focused on building and advancing a culture of inclusion that values and celebrates individual differences, uniqueness, backgrounds and perspectives. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to fostering a diverse and inclusive workplace that reflects the world around us and connects us to the patients, customers and communities we serve.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [e-mail] or call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Salary Range

$85,400.00 - $158,600.00

Skills Desired

Analytical Skill, Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Research, Clinical Trials, Collaboration, Communication Skills, Curiosity, Data, Data Analysis, Design Of Experiments, Detail-Oriented, Diversity & Inclusion, Drug Discovery, Ethics, Gene Therapy, Immunology, Laboratory, Lifesciences, Machine Learning (Ml), Mammalian Cell Culture, Medical Research, Molecular Biology {+ 11 more}