Senior Scientist I, Biomolecular Interactions

BioSpace; Worcester (MA); On-site; USD 90,000 - 130,000; Full time

Job summary

AbbVie in Worcester, MA, is seeking a highly skilled scientist to join the Biomolecular Interaction Team. The role focuses on analytical characterization of biopharmaceuticals, including monoclonal antibodies and multispecifics, using SPR and related technologies, with strong cross‑functional collaboration.

The candidate will contribute to discovery research by implementing high‑throughput assays, Fc characterization, and knowledge integration across therapeutic areas.

Qualifications

• PhD, MS or BS in Biochemistry, Biomedical Engineering or related field with typically 0‑4 years (PhD), 8+ years (MS), or 10+ years (BS) of experience.
• Experience in analytical/functional characterization of biologics using SPR platforms (e.g., Biacore and Carterra).
• Experience of high throughput biologics screening with biochemical, biophysical, and cell‑based methods.
• Possessing broad technical knowledge of a variety of analytical, biophysical, and structural methods, such as SEC, MS, HDX‑MS, X‑ray crystallography, DSF, DLS, etc. is a plus.
• Extensive knowledge in related functional areas, such as protein structure and function, antibody engineering, protein production and analytics is a plus.
• Excellent organizational skills and the ability to manage multiple projects simultaneously.
• Team player with the ability to operate in a fast‑paced multi‑disciplinary environment.
• Adapt to rapid changes in project priorities and timelines.
• Candidate must be a goal‑oriented team player with excellent verbal and written communication skills and strong can‑do attitude.
• Experience in managing internal/external collaboration is a plus.

Responsibilities

• Independently develop and execute SPR assays to generate objective selection criteria for panels of antibodies, multispecifics, and antibody‑like biologics.
• Evaluate and integrate protein‑protein interaction technologies to support therapeutic candidate selection.
• Implement high‑throughput epitope binning for large panels of monoclonal antibodies and develop knowledge of sequence/function relationships.
• Perform antibody Fc characterization studies to support regulatory submissions.
• Identify and solve technical problems independently; explore and develop new approaches to further advance characterization and screening technologies.
• Serve as a biologics lead for cross‑functional teams and contribute scientific insights across projects.
• Provide project updates, analysis and advice to cross‑functional teams and senior management.
• Present original work internally and at conferences; may author papers or patents.

Skills

Analytical characterization

High-throughput screening

Cross-functional teamwork

Communication skills

Education

PhD/MS/BS in Biochemistry or related field

Tools

SPR platforms

Biacore

Carterra

ELISA

FACS

SEC

MS

HDX-MS

X-ray crystallography

DSF

DLS

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

AbbVie's Biotherapeutics and Genetic Medicine, Protein Sciences Group, is seeking a highly skilled and self-motivated scientist to join our Biomolecular Interaction Team. This role offers the opportunity to make significant contributions to all Discovery Research Therapeutic Areas and Projects by providing analytical and functional characterization of our biopharmaceutical products, including monoclonal antibodies, multi-specifics and antibody-like biologics. The ideal candidate will have a strong understanding of high-throughput biologics screening and characterization methods (e.g., SPR, BLI, ELISA, FACS, etc.) and possess a solid foundation in protein sciences and antibody discovery with a proven ability to work effectively on cross-functional teams. This is an excellent opportunity for a highly motivated scientist to make a meaningful impact in a collaborative and innovative setting. Join us in bringing innovative medicines to patients!

Key Responsibilities

• Independently develop and execute SPR (Biacore and Carterra platforms) assays to generate objective selection criteria for panels of antibodies, multispecifics, and antibody-like biologics.
• Evaluate and integrate protein‑protein interaction technologies (e.g., SPR, BLI, ELISA, etc.) to support therapeutic candidate selection, demonstrating strong problem‑solving skills.
• Implement high‑throughput epitope binning for large panels of monoclonal antibodies and develop deep knowledge of antibody sequence/function relationships.
• Perform antibody Fc characterization studies to support regulatory submissions.
• Identify and solve technical problems independently; explore and develop new approaches to further advance innovative characterization and screening technologies.
• Serve as a biologics lead for cross‑functional teams and contribute scientific insights into multiple projects across various therapeutic areas; recognized and sought out as an expert in biomolecular interactions within the company and externally.
• Provide project updates, analysis and advice to cross‑functional teams and senior management.
• Present original work internally across departments and at internal/external scientific conferences; may author or co‑author peer‑reviewed scientific papers or patents.

Qualifications

• PhD, MS or BS in Biochemistry, Biomedical Engineering or related field with typically 0‑4 years (PhD), 8+ years (MS), or 10+ years (BS) of experience.
• Experience in analytical/functional characterization of biologics using Surface Plasmon Resonance (SPR) platforms (e.g., Biacore and Carterra).
• Experience of high throughput biologics screening with biochemical, biophysical, and cell‑based methods.
• Possessing broad technical knowledge of a variety of analytical, biophysical, and structural methods, such as SEC, MS, HDX‑MS, X‑ray crystallography, DSF, DLS, etc. is a plus.
• Extensive knowledge in related functional areas, such as protein structure and function, antibody engineering, protein production and analytics is a plus.
• Excellent organizational skills and the ability to manage multiple projects simultaneously.
• Team player with the ability to operate in a fast‑paced multi‑disciplinary environment.
• Adapt to rapid changes in project priorities and timelines.
• Candidate must be a goal‑oriented team player with excellent verbal and written communication skills and strong can‑do attitude.
• Experience in managing internal/external collaboration is a plus.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short‑term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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