Senior Scientist I, Biomolecular Interactions

AbbVie; Worcester (MA); On-site; USD 97,000 - 184,000; Full time

Benefits offered by this job

Paid time off (vacation/holidays)

Medical/dental/vision insurance

401(k)

Short-term incentive programs

Job summary

AbbVie invites applications for a Senior Scientist I, Biomolecular Interactions. The role focuses on developing SPR assays, integrating multiple technologies, and leading cross-functional biomolecule projects.

You will contribute to antibody discovery and regulatory submissions, while mentoring teams and presenting findings at conferences. The ideal candidate has a strong foundation in protein sciences, experience with SPR/BLI/ELISA, and a track record in high-throughput screening; collaboration

Qualifications

• PhD/MS/BS in Biochemistry, Biomedical Engineering or related field with typically 0–4 years (PhD), 8+ years (MS), or 10+ years (BS) of experience.
• Experience in analytical/functional characterization of biologics using SPR platforms (Biacore and Carterra).
• Experience with high-throughput biologics screening using biochemical, biophysical, and cell-based methods.
• Broad knowledge of analytical, biophysical, and structural methods (SEC, MS, HDX-MS, X-ray crystallography, DSF, DLS).
• Knowledge in protein structure/function, antibody engineering, protein production and analytics is a plus.
• Excellent organizational skills to manage multiple projects.
• Team player in fast-paced, multidisciplinary environment.
• Ability to adapt to changing priorities and timelines.
• Strong verbal and written communication, can-do attitude.
• Experience in managing internal/external collaboration is a plus.

Responsibilities

• Independently develop and execute SPR assays to generate objective selection criteria for panels of antibodies, multispecifics, and antibody-like biologics.
• Evaluate and integrate protein-protein interaction technologies (SPR, BLI, ELISA) to support candidate selection.
• Implement high-throughput epitope binning for large panels of monoclonal antibodies and study sequence/function relationships.
• Perform antibody Fc characterization studies to support regulatory submissions.
• Identify and solve technical problems; explore new approaches to advance characterization and screening technologies.
• Serve as a biologics lead for cross-functional teams and contribute insights across projects.
• Provide project updates, analysis and advice to cross-functional teams and senior management.
• Present original work to internal/external audiences; author or co-author papers or patents.

Skills

SPR characterization

High-throughput screening

Biologics analytics

Analytical/biophysical methods

Protein structure knowledge

Antibody engineering

Protein production

Project management

Cross-functional teamwork

Verbal and written communication

Education

PhD, MS or BS in Biochemistry, Biomedical Engineering or related field

Job description

Senior Scientist I, Biomolecular Interactions

• Full-time
• Salary Min: 96500
• Salary Max: 183500
• Workday Global Grade: 17
• Travel: Yes, 5% of the Time
• Compensation: USD 96,500 - USD 183,500 - yearly

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

AbbVie's Biotherapeutics and Genetic Medicine, Protein Sciences Group, is seeking a highly skilled and self-motivated scientist to join our Biomolecular Interaction Team. This role offers the opportunity to make significant contributions to all Discovery Research Therapeutic Areas and Projects by providing analytical and functional characterization of our biopharmaceutical products, including monoclonal antibodies, multi-specifics and antibody-like biologics. The ideal candidate will have a strong understanding of high-throughput biologics screening and characterization methods (e.g., SPR, BLI, ELISA, FACS, etc.) and possess a solid foundation in protein sciences and antibody discovery with a proven ability to work effectively on cross-functional teams. This is an excellent opportunity for a highly motivated scientist to make a meaningful impact in a collaborative and innovative setting. Join us in bringing innovative medicines to patients!

Key Responsibilities

• Independently develop and execute SPR (Biacore and Carterra platforms) assays to generate objective selection criteria for panels of antibodies, multispecifics, and antibody‑like biologics.
• Evaluate and integrate protein‑protein interaction technologies (e.g., SPR, BLI, ELISA, etc.) to support therapeutic candidate selection, demonstrating strong problem‑solving skills.
• Implement high‑throughput epitope binning for large panels of monoclonal antibodies and develop deep knowledge of antibody sequence/function relationships.
• Perform antibody Fc characterization studies to support regulatory submissions.
• Identify and solve technical problems independently; explore and develop new approaches to further advance innovative characterization and screening technologies.
• Serve as a biologics lead for cross‑functional teams and contribute scientific insights into multiple projects across various therapeutic areas; recognized and sought out as an expert in biomolecular interactions within the company and externally.
• Provide project updates, analysis and advice to cross‑functional teams and senior management.
• Present original work internally across departments and at internal/external scientific conferences; may author or co‑author peer‑reviewed scientific papers or patents.

Qualifications

• PhD, MS or BS in Biochemistry, Biomedical Engineering or related field with typically 0‑4 years (PhD), 8+ years (MS), or 10+ years (BS) of experience.
• Experience in analytical/functional characterization of biologics using Surface Plasmon Resonance (SPR) platforms (e.g., Biacore and Carterra).
• Experience of high throughput biologics screening with biochemical, biophysical, and cell‑based methods.
• Possessing broad technical knowledge of a variety of analytical, biophysical, and structural methods, such as SEC, MS, HDX‑MS, X‑ray crystallography, DSF, DLS, etc. is a plus.
• Extensive knowledge in related functional areas, such as protein structure and function, antibody engineering, protein production and analytics is a plus.
• Excellent organizational skills and the ability to manage multiple projects simultaneously.
• Team player with the ability to operate in a fast‑paced multi‑disciplinary environment.
• Adapt to rapid changes in project priorities and timelines.
• Candidate must be a goal‑oriented team player with excellent verbal and written communication skills and strong can‑do attitude.
• Experience in managing internal/external collaboration is a plus.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at thetimeofthis posting based on the job grade for this position. Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemay ultimately pay more or less than the posted range. This range may be modified in thefuture.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• Paid time off (vacation, holidays, sick)
• Medical/dental/vision insurance
• 401(k) to eligible employees
• This job is eligible to participate in our short‑term incentive programs.

This job is eligible to participate in our short‑term incentive programs.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or anyotherformofcompensationandbenefits that are allocable to a particular employeeremains in the Company'ssoleandabsolutediscretion unless and until paid andmaybemodified at the Company'ssoleandabsolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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