Senior Scientist I, Experimental & Systems Immunology

BioSpace; Cambridge (MA); On-site; USD 120,000 - 170,000; Full time

Job summary

AbbVie in Cambridge, MA, seeks a Senior Scientist I to advance autoimmune and inflammatory disease targets by integrating experimental immunology with quantitative data analysis. The role blends wet-lab work on human cells and advanced in vitro models with computational interpretation, contributing to discovery programs and portfolio decisions.

You will design complex immunology experiments, analyze high-dimensional data, and collaborate across multidisciplinary teams, mentoring junior

Qualifications

• BS/BA, MS, or PhD in Immunology, Molecular Biology, Cell Biology, or related field with 0–3+ (PhD), 8–9+ (MS), or 10–11+ (BS) years experience.
• Strong immunology background and immune-mediated diseases.
• Hands‑on with primary human samples (PBMCs, tissues).
• Experience with organoids or complex co‑culture systems.
• Techniques: flow cytometry, ELISA/multiplex assays, gene expression.
• Ability to analyze and communicate complex datasets.
• Statistical knowledge and tools (R, Python, GraphPad Prism, Spotfire).
• Experience in multidisciplinary teams.

Responsibilities

• Design, execute, and interpret immunology experiments using human cells and tissues.
• Work with advanced in vitro models (organoids, co-cultures) and high-throughput assays.
• Develop assays to characterize immune function and mechanisms of action.
• Generate and analyze data from flow cytometry, cytokine profiling, and NGS-based approaches.
• Collaborate with computational biologists and translational scientists to prioritize targets.
• Apply statistics to complex datasets and communicate findings clearly.
• Maintain records and contribute to scientific reports and reviews.
• Stay current with immunology advances and incorporate new approaches.

Skills

Immunology expertise

Experimental design

Primary human samples

Organoid models

Flow cytometry

Data analysis

Team collaboration

Education

PhD in Immunology

MS in related field

BS in related field

Tools

R

Python

GraphPad Prism

Spotfire

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio.

For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

AbbVie's Immunology Discovery organization is seeking a highly motivated Senior Scientist I to join our Immune Profiling Systems Immunology team within the Discovery Immunology organization in Cambridge, Massachusetts. The successful candidate will contribute to the identification, validation, and prioritization of novel therapeutic targets for autoimmune and inflammatory diseases through the integration of experimental immunology and quantitative data analysis.

This role is ideal for a scientist who enjoys working at the interface of wet-laboratory experimentation and computational analysis. The candidate will design and execute human disease-relevant experiments, with an emphasis on complex in vitro models such as organoids or complex co-culture systems and their characterization using a range of high-throughput methodologies. They will generate high-dimensional datasets, analyze and interpret results, and collaborate across multidisciplinary teams to advance discovery programs and portfolio decisions.

Key Responsibilities

• Design, execute, and interpret immunology-focused experiments using primary human cells, PBMCs, tissues, and disease-relevant model systems.
• Design and execute studies using complex in vitro models, including organoids or complex co-culture systems, and characterize these models using a range of high-throughput methodologies, such as multiplexed assays and sequencing-based profiling.
• Develop and implement assays to characterize immune cell function, signaling pathways, cellular phenotypes, and therapeutic mechanisms of action.
• Generate and analyze data from flow cytometry, cytokine profiling, NGS-based approaches, single-cell and spatial profiling workflows, and other molecular profiling platforms.
• Partner with computational biologists, bioinformaticians, translational scientists, and disease-area teams to develop mechanistic insights and prioritize therapeutic targets.
• Apply statistical and computational approaches to analyze complex datasets and communicate findings clearly to multidisciplinary audiences.
• Maintain accurate experimental records and contribute to scientific reports, presentations, and project reviews.
• Stay current with advances in immunology, translational research, systems biology, and emerging technologies and incorporate new approaches into discovery programs.
• Present findings to project teams, leadership, and external scientific forums as appropriate.
• Contribute to the scientific culture through collaboration, mentorship of junior scientists, and sharing of technical expertise.

Qualifications

BS/BA, MS, or PhD in in Immunology, Molecular Biology, Cell Biology, or a related scientific discipline with typically 0-3+ (PhD), 8-9+ (MS), or 10-11+ (BS) years of relevant academic and/or industry experience.

• Strong scientific background in immunology and immune-mediated diseases.
• Demonstrated expertise in experimental design, execution, and interpretation.
• Hands‑on experience working with primary human samples, including PBMCs, tissues, or disease‑relevant cellular systems.
• Hands‑on experience working with complex in vitro models, such as organoids or complex co‑culture systems, and applying high‑throughput methodologies to characterize their cellular and functional properties.
• Experience with immunological and molecular biology techniques such as flow cytometry, cell culture, ELISA/multiplex cytokine assays, gene expression analysis, and other functional assays.
• Demonstrated ability to analyze, interpret, and communicate complex biological datasets.
• Working knowledge of statistical methods and data analysis tools such as R, Python, GraphPad Prism, Spotfire, or equivalent platforms.
• Proven ability to work effectively in multidisciplinary teams and contribute to project advancement.

Preferred

• Experience with single‑cell genomics, spatial biology, multi‑omics profiling, and next‑generation sequencing technologies (e.g., 10x Genomics Chromium 3′/5′ gene expression, Flex).
• Experience in target identification, target validation, reverse translation, or mechanism‑of‑action studies.
• Familiarity with systems immunology and integration of experimental and computational datasets.
• Experience applying data science approaches to biological questions.
• Track record of scientific publications, patents, or presentations at major scientific meetings.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

This job is eligible to participate in our short‑term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

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https://www.abbvie.com/join-us/reasonable-accommodations.html