Senior Scientist I - BDL Modeling

AbbVie; Worcester (MA); On-site; USD 97,000 - 184,000; Full time

Job summary

AbbVie in Worcester is seeking a Senior Scientist I to join a centralized bioprocess modeling team. You will develop and apply models for upstream cell culture and downstream purification across early- and late-stage programs, collaborating with IT, Data Science, CMC, and Development to drive scalable solutions.

The role emphasizes translating scientific challenges into modeling approaches and delivering insights with AI-assisted tools, while ensuring compliance with safety and GxP standards.

Qualifications

• Bachelor’s degree with extensive bioprocess experience; or advanced degrees with appropriate experience.
• Background in chemical/biomedical engineering or biotechnology preferred.
• Experience in upstream and downstream development; CFD, chromatography, and filtration modeling preferred.

Responsibilities

• Independently build and apply models for upstream cell culture and downstream purification.
• Translate scientific and business challenges into modeling strategies.
• Advance modeling capabilities through AI tool integration and rapid implementation.

Skills

CFD modeling

Cell culture

Metabolic flux balance

Chromatography modeling

Filtration theory

Education

Bachelor’s degree

Master’s degree

PhD

Tools

AI tools integration

Bioprocess software

Job description

• Compensation: USD 96,500 - USD 183,500 - yearly

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

Job Description

The Senior Scientist I will be part of a centralized modeling team supporting the development and implementation of a broad range of models across early- and late-stage bioprocess development for diverse biologic modalities, including monoclonal antibodies, antibody-drug conjugates, bispecifics, and gene therapies. Working collaboratively across functions, the scientist will develop and apply innovative modeling and experimental approaches to address scientific and process development challenges, including scale-up and technology transfer. The team’s mission is to continually build next-generation modeling capabilities through deep integration with artificial intelligence (AI) tools, delivering business impact with agility.

Responsibilities:

• Independently conceptualize, build, and apply fit-for-purpose models for upstream cell culture and downstream purification processes across early- and late-stage bioprocess development.
• Translate scientific and business challenges into modeling strategies that deepen process understanding, guide process optimization, and support scale-up and technology transfer.
• Advance next-generation modeling capabilities through deep integration with AI tools to accelerate model development and implementation and deliver business impact with agility.
• Work closely with the Automation and Digitalization team to establish data workflows and integrated tools that enable efficient model building and implementation.
• Integrate multidisciplinary data and scientific fundamentals to assess model performance, assumptions, and limitations, draw actionable conclusions, and resolve key project challenges.
• Collaborate in an agile, fast-paced matrix team spanning IT, Data Science, CMC, and Development to align priorities, adapt to evolving needs, and deliver modeling solutions; provide scientific mentorship and technical guidance as appropriate.
• Communicate modeling approaches, results, limitations, and recommendations clearly and efficiently to project teams and leadership to support timely, informed decisions.
• Support model transfer and lifecycle management, including implementation, documentation, maintenance, updates, and assessment of continued fitness for purpose, in accordance with applicable corporate, safety, and GxP standards.
• Serve as a primary author of modeling-related technical and regulatory documents, peer-reviewed publications, and scientific presentations, and contribute to patentable innovations as appropriate.
• Proactively evaluate relevant literature and emerging technologies, identify innovative modeling opportunities aligned with the centralized team’s strategy, and incorporate advances into projects and broader modeling capabilities.

Qualifications

• Bachelor’s degree or equivalent education and typically 10 years of experience, Master’s degree or equivalent education and typically 8 years of experience, PhD degree or equivalent education and 0-2 years of experience.
• Education background in chemical engineering, biomedical engineering, biochemistry, biochemical engineering, or biotechnology is preferred.
• Experience in both upstream cell culture and downstream purification process development is preferred. Demonstrated expertise in computational fluid dynamics (CFD) modeling, cell culture kinetics and metabolic flux balance modeling, chromatography modeling, and filtration theory and modeling is preferred.
• Familiarity with AI tool development and experience integrating AI tools into the bioprocess development ecosystem.
• Demonstrate excellent communication skills and specifically illustrate strong oral and written technical communications. Seamlessly present research outcomes to multifunctional teams
• Play a strong team player in a cross functional collaborative environment thriving for world class excellence and maintains strong working relationships with internal, global, and external collaborators.
• Demonstrated problem-solving skills and capability to overcome complex issues.
• Demonstrated success in coordinating and executing important projects to achieve business goals.
• Must have a “results-oriented” work ethic and a positive “can-do” attitude with a strong sense of urgency and self-motivated desire to achieve.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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