Principal Research Scientist I - Analytical Development - PDST - Late-Stage Process...

University of Georgia- FACS; Waltham (MA); On-site; USD 130,000 - 180,000; Full time

Benefits offered by this job

Medical/dental/vision insurance

Paid time off

401(k) with company match

Long-term incentive programs

Job summary

AbbVie is seeking a Principal Scientist I to lead analytical activities within the Process Analytics team in Biologics. You will guide high-throughput testing for late-stage programs, serving as SME for separation methods including HPLC and capillary electrophoresis, and drive method development and automation with cross-functional partners.

The role demands a PhD or MS with extensive experience, strong leadership, and excellent communication to foster a collaborative lab environment.

Qualifications

• PhD with 6+ years in analytical development or process analytics; MS with 10+ years acceptable.
• Proven leadership of analytical development for biologics (mAbs, ADCs, fusion proteins).
• Hands-on method development in protein/impurity analysis (HPLC, CE, related).
• Experience with automation and cross-functional collaboration.

Responsibilities

• Lead analytical activities in high-throughput testing for biologics late-stage programs.
• Serve as SME for separation methods (HPLC, capillary electrophoresis).
• Evaluate/select fit-for-purpose analytics to meet PD needs.
• Provide method development, execution, troubleshooting, and guidance.
• Mentor and supervise junior scientists; coordinate sample testing schedules.
• Partner with PD SMEs to interpret analytical data.
• Drive automation implementations and high-throughput workflows.
• Drive continuous improvement to enhance lab efficiency and capability.

Skills

Leadership

Cross-functional collaboration

Analytical reasoning

Troubleshooting

Communication

Education

PhD in chemistry, biology, biochemistry, chemical engineering or related

MS with 10+ years of experience

Tools

HPLC

Capillary electrophoresis

Mass spectrometry

ELISA

Automation

Job description

ICompany Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

The Principal Scientist I will be an integral part of the Process Analytics team in the Operations - Product Development Science and Technology - Biologics division. The role involves leading analytical activities within a high-throughput testing group supporting biologics products with a focus on advancing AbbVie's late-stage clinical programs. This position calls for an individual with a strong technical analytical background, demonstrated leadership and organizational skills and the ability to effectively communicate and work cross-functionally.

Responsibilities:

• Lead analytical activities within a high-throughput testing group supporting biologics process development for late-stage programs.
• Serve as the subject matter expert for separation-based methods, including HPLC and capillary electrophoresis.
• Evaluate and select effective fit for purpose analytical technologies and methods to meet process development needs.
• Provide expertise and support for method development, execution, and troubleshooting. Provide direct technical guidance and oversight to scientists executing sample testing with hands on lab support when needed.
• Partner with process development SMEs for interpretation and understanding of analytical data.
• Oversee sample testing schedule and prioritization; drive timely delivery of high-quality testing results.
• Support implementation of automation and high-throughput experimentation workflows.
• Drive continuous improvement initiatives to enhance lab efficiency and capability.
• Mentor, train and supervise junior scientists.

Qualifications

• PhD in chemistry, biology, biochemistry, chemical engineering, or related technical discipline with 6+ years of relevant professional experience working in analytical development or process analytics; MS degree with minimum of 10+ years of relevant experience.
• Proven experience leading analytical development activities for biologics development, including mAbs, multi-specifics, antibody-drug conjugates, and fusion proteins.
• Hands on method development experience in protein and impurity analysis techniques such as HPLC, capillary electrophoresis, and other relevant methods for biologics required. Experience with mass spectrometry and ELISA is a plus.
• Previous experience with automation is a plus.
• Highly organized with ability to multitask and drive efficient workflows.
• Ability to think critically and demonstrate troubleshooting and problem-solving skills.
• Strong people leadership skills and demonstrated ability to foster an engaging, inclusive and collaborative team environment. Direct people management experience required.
• Excellent communication and interpersonal skills. Ability to work effectively across functions, anticipating and addressing overall program development needs.
• An independent, self-motivated, proactive individual who thrives in a fast-paced team environment.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our long-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.htmlI