Senior Scientist I - BDL Modeling

AbbVie Inc.; Worcester (MA); On-site; USD 110,000 - 170,000; Full time

Benefits offered by this job

Paid time off

Medical insurance

401(k)

Job summary

AbbVie Inc. is seeking a Senior Scientist I to join a centralized modeling team supporting upstream/downstream bioprocess development for diverse biologic modalities.

You will develop fit-for-purpose models, integrate AI tools, and collaborate across IT, Data Science, CMC, and Development to accelerate scale-up and tech transfer. The role emphasizes translating scientific challenges into modeling strategies, documenting methods, and contributing to lifecycle management and regulatory documents

Qualifications

• PhD or equivalent in bioprocess related field with strong modeling background.
• Experience in upstream/downstream bioprocess modeling and OOS/CFD is preferred.
• Familiarity with AI tool development and integration into bioprocess ecosystem.

Responsibilities

• Conceptualize and build fit-for-purpose models for bioprocess development.
• Translate scientific challenges into modeling strategies and support scale-up/tech transfer.
• Advance AI-enabled modeling capabilities and integrate with data workflows.
• Collaborate with IT, Data Science, CMC and Development teams.
• Author modeling-related technical/regulatory documents and present findings.

Skills

Bioprocess modeling

AI integration

Cell culture

Experimental design

Data analysis

Cross-functional collaboration

Education

PhD in Bioprocessing

Masters in Biochemical Eng

Bachelor's in Chemical Eng

Tools

CFD software

Process simulation

Python

Job description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

The Senior Scientist I will be part of a centralized modeling team supporting the development and implementation of a broad range of models across early- and late-stage bioprocess development for diverse biologic modalities, including monoclonal antibodies, antibody-drug conjugates, bispecifics, and gene therapies. Working collaboratively across functions, the scientist will develop and apply innovative modeling and experimental approaches to address scientific and process development challenges, including scale-up and technology transfer. The team’s mission is to continually build next-generation modeling capabilities through deep integration with artificial intelligence (AI) tools, delivering business impact with agility.

Responsibilities

• Independently conceptualize, build, and apply fit-for-purpose models for upstream cell culture and downstream purification processes across early- and late-stage bioprocess development.
• Translate scientific and business challenges into modeling strategies that deepen process understanding, guide process optimization, and support scale-up and technology transfer.
• Advance next-generation modeling capabilities through deep integration with AI tools to accelerate model development and implementation and deliver business impact with agility.
• Work closely with the Automation and Digitalization team to establish data workflows and integrated tools that enable efficient model building and implementation.
• Integrate multidisciplinary data and scientific fundamentals to assess model performance, assumptions, and limitations, draw actionable conclusions, and resolve key project challenges.
• Collaborate in an agile, fast-paced matrix team spanning IT, Data Science, CMC, and Development to align priorities, adapt to evolving needs, and deliver modeling solutions; provide scientific mentorship and technical guidance as appropriate.
• Communicate modeling approaches, results, limitations, and recommendations clearly and efficiently to project teams and leadership to support timely, informed decisions.
• Support model transfer and lifecycle management, including implementation, documentation, maintenance, updates, and assessment of continued fitness for purpose, in accordance with applicable corporate, safety, and GxP standards.
• Serve as a primary author of modeling-related technical and regulatory documents, peer-reviewed publications, and scientific presentations, and contribute to patentable innovations as appropriate.
• Proactively evaluate relevant literature and emerging technologies, identify innovative modeling opportunities aligned with the centralized team’s strategy, and incorporate advances into projects and broader modeling capabilities.

Education and Experience

Bachelor’s degree or equivalent education and typically 10 years of experience, Master’s degree or equivalent education and typically 8 years of experience, PhD degree or equivalent education and 0-2 years of experience.

Education background in chemical engineering, biomedical engineering, biochemistry, biochemical engineering, or biotechnology is preferred.

Experience in both upstream cell culture and downstream purification process development is preferred. Demonstrated expertise in computational fluid dynamics (CFD) modeling, cell culture kinetics and metabolic flux balance modeling, chromatography modeling, and filtration theory and modeling is preferred.

Familiarity with AI tool development and experience integrating AI tools into the bioprocess development ecosystem.

Demonstrate excellent communication skills and specifically illustrate strong oral and written technical communications. Seamlessly present research outcomes to multifunctional teams

Play a strong team player in a cross functional collaborative environment thriving for world class excellence and maintains strong working relationships with internal, global, and external collaborators.

Demonstrated problem-solving skills and capability to overcome complex issues.

Demonstrated success in coordinating and executing important projects to achieve business goals.

Must have a “results-oriented” work ethic and a positive “can-do” attitude with a strong sense of urgency and self-motivated desire to achieve.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html