Director, Antibody Engineering & Discovery

iBio, Inc.; San Diego (CA); On-site; USD 184,000 - 244,000; Full time

Benefits offered by this job

Medical, dental, and vision insurance

401(k) with company match

Life insurance

Short-term and long-term disability

Flexible time off

Job summary

iBio, Inc. in San Diego, CA, seeks an experienced scientific leader to direct the Antibody Engineering and Discovery team, overseeing protein expression, purification, molecular engineering, characterisation, and screening.

The role will lead programs from antibody sequences and hits emerging from iBio’s discovery platform through lead optimization and delivery of well-characterized molecules for in vivo proof-of-concept studies with the translational team.

Qualifications

• PhD or MS/BS with extensive biotech background in antibody discovery.
• Proven track record advancing therapeutic antibodies from discovery to in vivo proof-of-concept.
• Experience designing multispecific antibodies and antibody-peptide conjugates or peptide fusions.

Responsibilities

• Lead and develop the Antibody Engineering and Discovery team with clear priorities and objectives.
• Oversee construction design, expression, purification, and screening to deliver material for in vivo studies.
• Guide lead optimization, binding kinetics, selectivity, and developability assessments for candidate molecules.
• Partner with platform, computational, and translational teams to translate insights into testing hypotheses.
• Present data and recommendations to senior leadership and maintain rigorous documentation.

Skills

Antibody engineering

Protein expression

Mammalian cell culture

Biochemical assays

Lead optimization

Project leadership

Education

PhD in protein engineering or related field

MS in biochemistry

Tools

SEC

CE-SDS

Mass spectrometry

SPR/BLI

Mammalian expression systems

Job description

iBio, Inc. in San Diego, CA, seeks an experienced scientific leader to direct the Antibody Engineering and Discovery team, overseeing protein expression, purification, molecular engineering, characterisation, and screening.

The role will lead programs from antibody sequences and hits emerging from iBio’s discovery platform through lead optimization and delivery of well-characterized molecules for in vivo proof-of-concept studies with the translational team.