Senior Scientist, Gene Delivery and Editing Process Development , Cell TherapyDevelopment

Bristol Myers Squibb; Washington (District of Columbia); On-site; USD 140,000 - 190,000; Full time

Benefits offered by this job

Health insurance

Job summary

Bristol Myers Squibb seeks a Senior Scientist to lead formulation and drug product development for viral vectors, mRNA, and lipid nanoparticle systems used in gene therapy and cell engineering. The role emphasizes biophysical stability, freeze/thaw behavior, lyophilization, and cold-chain reduction strategies.

You will transition formulations through clinical and commercial manufacturing, perform stability studies, and support tech transfer with CMOs/CROs, while authoring technical and

Qualifications

• Ph.D. in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field; or MS/BS with 6+ years of relevant experience.
• Expertise in biophysical and colloidal stability of biologics and advanced-modality products.
• Experience with regulatory documentation, cGMP, and ICH guidelines.
• Hands-on with freeze/thaw and frozen-state stability studies.
• Strong technical writing and oral communication skills.

Responsibilities

• Design and execute formulation studies for viral vectors and nucleic acid/LNP products across liquid, frozen, and lyophilized presentations.
• Lead freeze/thaw, cryopreservation, and lyophilization cycle development; characterize freeze-concentration and collapse effects on product attributes.
• Apply biophysical characterization to elucidate degradation mechanisms and guide formulation optimization decisions.
• Design and interpret stability studies to support shelf-life and storage claims; maintain documentation in electronic laboratory notebook.
• Support technology transfer and process scale-up activities; develop relationships with external CMOs and CROs; author technical and regulatory reports.

Skills

Biophysics

Viral vectors

Nucleic acid/LNP formulation

Cryopreservation

Lyophilization

Stability studies

Technical writing

Oral communication

Education

PhD in Pharmaceutical Sciences

MS/BS with 6+ years relevant experience

Tools

DSC/mDSC

Dynamic light scattering

Freeze-drying microscopy

Job description

Bristol Myers Squibb seeks a Senior Scientist to lead formulation and drug product development for viral vectors, mRNA, and lipid nanoparticle systems used in gene therapy and cell engineering. The role emphasizes biophysical stability, freeze/thaw behavior, lyophilization, and cold-chain reduction strategies, with responsibility for transitioning formulations through clinical and commercial manufacturing.

Responsibilities

• Design and execute formulation studies for viral vectors and nucleic acid/LNP products across liquid, frozen, and lyophilized presentationsLead freeze/thaw, cryopreservation, and lyophilization cycle development; characterize freeze-concentration and collapse behavior impacts on product attributesApply biophysical characterization to elucidate degradation mechanisms and guide formulation optimization decisionsDesign and interpret stability studies to support shelf-life and storage claims; maintain documentation in electronic laboratory notebookSupport technology transfer and process scale-up activities; develop relationships with external CMOs and CROs; author technical and regulatory reports

Requirements

• Demonstrated expertise in biophysical and colloidal stability of biologics and advanced-modality productsHands-on experience with freeze/thaw and frozen-state stability studiesWorking proficiency with DSC/mDSC, freeze-drying microscopy, and dynamic light scattering techniquesAbility to design buffer, cryoprotectant, and surfactant systems from first principlesPh.D. in Pharmaceutical Sciences, Chemistry, Biochemistry, or Chemical/Biomedical Engineering; or M.S./B.S. with 6+/10+ years relevant experienceExperience with regulatory documentation, cGMP, and ICH guidelinesStrong technical writing and oral communication skills for diverse audiences