Senior Scientist, Functional Screening & Antibody Biology

Bristol Myers Squibb; Virginia (MN); On-site; USD 141,000 - 171,000; Full time

Job summary

Bristol Myers Squibb is seeking a Senior Scientist in the Discovery Biotherapeutics group to lead cell biology–driven assay development for antibody therapeutics. You will design and execute functional screening strategies, generate testable hypotheses, and collaborate across bioscience teams.

The role emphasizes hands-on cellular assays, imaging, and data analysis, with opportunities for matrix management and cross-site collaboration in a fast-paced, impact-focused environment.

Qualifications

• Bachelor’s degree with relevant research experience in molecular/cell biology and immunology preferred.
• Experience designing and interpreting functional characterization assays for antibody therapeutics.
• Hands-on cellular assays with diverse readouts to dissect mechanism of action; antibodies/biologics experience required.
• Flow cytometry and imaging experience essential; Incucyte or similar platforms advantageous.

Responsibilities

• Design and implement cellular screening assays for antibody-based biologics to identify lead candidates.
• Develop mechanistic assays for antibody modalities and target profiles.
• Create and optimize cell lines and assays including reporter assays and imaging-based readouts.
• Characterize protein reagents for in vitro selection and assay components.
• Support target ideation and hypothesis generation for validation.
• Leverage automation and AI/ML to improve screening and data analysis workflows.
• Represent Discovery Biotherapeutics in multi-disciplinary project teams and present data.
• Document experiments meticulously in Electronic Notebook and upload data into Benchling.

Skills

Cell biology

Immunology

Antibody therapeutics

Flow cytometry

Incucyte

Imaging

Automation

Data visualization

Education

Bachelor’s Degree

Master’s Degree

PhD

Tools

Benchling

Job description

Bristol Myers Squibb is seeking a Senior Scientist in the Discovery Biotherapeutics group to lead cell biology–driven assay development for antibody therapeutics. You will design and execute functional screening strategies, generate testable hypotheses, and collaborate across bioscience teams.

The role emphasizes hands-on cellular assays, imaging, and data analysis, with opportunities for matrix management and cross-site collaboration in a fast-paced, impact-focused environment.