Senior Scientist, DMPK

Eisai US; Cambridge (MA); On-site; USD 100,000 - 150,000; Full time

Job summary

Eisai US is seeking a Senior Scientist in DMPK to lead scientific initiatives in drug metabolism and pharmacokinetics. This role involves managing DMPK strategies across various projects, ensuring regulatory compliance, and mentoring junior staff. Ideal candidates will have a Ph.D. and extensive experience in the pharmaceutical industry, contributing to innovative drug development efforts.

Qualifications

• Ph.D. with at least 5 years of relevant industry experience.
• Strong expertise in DMPK principles and regulatory submissions.
• Proven track record in drug discovery and development projects.

Responsibilities

• Lead DMPK project management for drug discovery and development.
• Provide strategic DMPK input to project teams.
• Mentor junior team members and facilitate collaborations.

Skills

DMPK principles

ADME

PK/PD

Regulatory submissions

Communication skills

Collaboration skills

Education

Ph.D. in pharmacokinetics, drug metabolism, or pharmaceutical sciences

Job description

Join to apply for the Senior Scientist, DMPK role at Eisai US

At Eisai, our mission is to satisfy unmet medical needs and enhance healthcare benefits for patients, families, and caregivers. We are a growing pharmaceutical company pioneering in neurology and oncology, with a focus on research and development. Our history includes the development of innovative medicines, notably the discovery of the world's most widely-used treatment for Alzheimer’s disease. We seek highly motivated individuals eager to work in a fast-paced environment and make a difference. If this describes you, we want to hear from you.

Role Overview

The Senior Scientist, DMPK will provide scientific leadership and project management support for drug metabolism and pharmacokinetics (DMPK) activities across multiple discovery and development programs. This role is a key DMPK representative for projects at various stages, from early discovery to IND-enabling and clinical development, ensuring successful integration of DMPK strategies into drug development pipelines.

Essential Functions

1. Serve as the DMPK project manager and representative for multiple drug discovery and development projects, including internal and collaborative programs.
2. Provide strategic DMPK input and guidance to multidisciplinary project teams to ensure timely decision-making for project advancement, especially during discovery stages.
3. Manage and interpret in vitro and in vivo ADME, PK, and PK/PD data to support lead optimization and candidate selection.
4. Collaborate with internal and external partners to design and execute discovery and IND-enabling DMPK studies, ensuring regulatory compliance and data integrity.
5. Facilitate cross-functional collaboration with global health teams, academic institutions, and external partners on discovery and development projects.
6. Mentor and guide junior team members, supporting their professional growth.
7. Represent the global Eisai DMPK team in IQ Working group.

Requirements

1. Ph.D. in pharmacokinetics, drug metabolism, pharmaceutical sciences, or a related field with at least 5 years of relevant industry experience.
2. Strong expertise in DMPK principles, including in vitro and in vivo ADME, PK/PD, and IND-enabling studies.
3. Experience with regulatory submissions (IND, NDA) and understanding of FDA and ICH guidelines.
4. Proven track record of managing DMPK aspects of drug discovery and development projects.
5. Excellent communication and collaboration skills, with experience working in multidisciplinary teams.
6. Ability to multitask and manage multiple projects efficiently in a fast-paced environment.