Scientist II, Degrader Antibody Conjugate Characterization

Initial Therapeutics, Inc.; Brisbane (CA); On-site; USD 140,000 - 161,000; Full time

Job summary

Nurix Therapeutics, Inc. seeks a scientist to lead analytical workflows for the DAC platform, applying ADC/DAC characterization to advance programs.

The role requires assay design, method development, hands-on execution, and clear cross-functional communication from screening to candidate selection. You will set QC criteria, optimize LCMS/HPLC methods, and integrate DAR, purity, and stability data into go/no-go decisions.

Qualifications

• BS/BA with 12+, MS/MA with 8+, or PhD with 4+ years in biochemistry or analytical chemistry.
• Expertise in ADC/DAC and antibody characterization from method development to data interpretation.
• Experience with LCMS and HPLC for antibody/conjugate analysis (DAR, SEC, mapping).
• Experience characterizing ADCs in industry with conjugation chemistry knowledge.
• Proven ability to design experiments, develop methods, and troubleshoot instruments.
• Ability to translate complex data into actionable scientific conclusions for teams.

Responsibilities

• Design, execute and own the DAC screening platform (DAR, aggregation, protein quantitation).
• Lead and conduct in-depth characterization of antibodies and advanced DACs including positional isomers, glycosylation analysis, peptide mapping, and stability.
• Integrate DAR, purity, hydrophobicity, and stability data into unified assessments with QC cutoffs.
• Develop, optimize, and troubleshoot LCMS and HPLC methods for throughput and robustness.
• Present findings to project and platform teams and coordinate sample flow and decisions.

Skills

ADC/DAC analysis

LCMS methods

HPLC methods

Antibody analysis

Data interpretation

Method development

Go/no-go decisions

Cross-functional comms

Experiment design

Education

BS/BA in Biochemistry

MS/MA in Analytical Chemistry

PhD in related field

Tools

MassHunter

Byos

Job description

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

You will lead the development of innovative analytical workflows that support and accelerate Nurix's DAC platform, applying your expertise in ADC and/or DAC characterization to solve complex scientific challenges. This is an opportunity to shape analytical strategy for a novel therapeutic platform at the forefront of drug discovery and development.

This is a laboratory role requiring assay design, method development, hands-on execution, and scientific communication to project and platform teams. You will design and execute analytical strategies for high-throughput DAC screening, establish quality criteria that drive conjugate advancement decisions, and partner closely with conjugation chemistry, biology, and bioanalytical teams from early screening through candidate selection.

Responsibilities

• Design, execute and own the DAC screening characterization platform including DAR, aggregation, protein quantitation, and define the QC thresholds to advance conjugates for a program
• Lead and conduct in-depth characterization of antibodies and advanced DACs including positional isomers, glycosylation analysis, peptide mapping, and stability
• Integrate DAR, purity, hydrophobicity, and stability data into unified assessments with QC cutoffs that drive go/no-go decisions; identify structure-quality trends across antibody, linker, and payload variables
• Develop, optimize, and troubleshoot LCMS and HPLC methods for throughput and robustness; establish plate-based sample preparation workflows that maintain data quality at screening scale
• Present findings to project and platform teams; collaborate with conjugation chemistry, bioanalytical, and cell screening groups to align workflows, coordinate sample flow, and influence conjugate advancement decisions

Requirements

• BS/BA with 12+, MS/MA with 8+, or PhD with 4+ years of industry experience in biochemistry, analytical chemistry, or a related discipline
• Expertise in ADC/DAC & antibody characterization from method development to data interpretation
• Expertise with LCMS & HPLC methods for antibody and conjugate analysis, including DAR, SEC, peptide mapping, HIC, and other relevant industry leading methods
• Direct experience characterizing ADCs in an industry setting with working knowledge of conjugation chemistry, DAR heterogeneity, and common quality attributes
• Track record of independently designing experiments, developing analytical methods, troubleshooting assay and instrument performance, and managing priorities across multiple concurrent programs
• Ability to synthesize complex analytical datasets into actionable scientific conclusions and influence project decisions through clear communication to cross-functional teams

Preferred Qualifications

• Experience with native LCMS, positional isomer analysis, glycan analysis, CE-SDS for expanded conjugate or antibody characterization
• Background in peptide mapping, biophysical binding assays, and thermal stability
• Familiarity with developability assessment, forced degradation, or formulation-support analytics for biologics
• Familiarity & experience with Agilent instrumentation & analytical software (MassHunter, Byos, or equivalent)

Culture & Team Fit

• Ability to work collaboratively across multiple groups within the organization
• Excellent organization and communication with effective presentation skills
• Self-driven and enthusiastic with proficiencies to deliver in a dynamic environment
• Curious mindset with a willingness and flexibility to learn new skills
• High level of creativity and productivity with strong problem-solving skills

Salary Range: 140K - 161K

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