Senior Scientist, Computational Biology - Preclinical AI

Sail Biomedicines; Cambridge (MA); On-site; USD 130,000 - 170,000; Full time

Job summary

Sail Biomedicines in Cambridge, MA is seeking a Senior Scientist I in Computational Biology to advance In VivoCAR-T programs and platform development. You will lead data-driven analyses across preclinical datasets, develop and benchmark methods, and contribute to capabilities spanning molecular modeling and AI-based therapeutic engineering.

The ideal candidate has a PhD and 3+ years in biotech or academia, with strong Python/R skills and a track record of leading computational projects while

Qualifications

• Ph.D. in Computational Biology, Bioinformatics, Systems Biology, Biophysics, or a related quantitative discipline.
• 3+ years of hands-on computational biology research in biotech, pharma, or academia.
• Record of independently leading substantial computational biology projects and developing/benchmarking analytical methods.
• Deep expertise in transcriptomics, multi-omics analysis, or quantitative analysis of preclinical studies.
• Strong grounding in statistical modeling addressing confounding, batch effects, and experimental design limitations.
• Strong programming skills in Python and/or R with reproducible workflows.

Responsibilities

• Lead analysis of preclinical research datasets, including immunophenotyping, functional assays, and multi-omics data to support therapeutic development.
• Develop, adapt, and benchmark computational and statistical methods to address complex biological questions.
• Integrate and interpret data across studies to contextualize findings and strengthen understanding of therapeutics.
• Partner with experimental scientists to shape experimental design, interpret results, and prioritize follow-up studies.
• Build and maintain reproducible analysis workflows with clear documentation and version control (Git).
• Communicate findings, uncertainty, and implications with collaborators through visualizations, presentations, and written summaries.

Skills

Python

R

Multi-omics

Transcriptomics

Statistical modeling

Data visualization

Education

Ph.D. in Computational Biology or related

Tools

Git

R

Python

Job description

Sail Biomedicines in Cambridge, MA is seeking a Senior Scientist I in Computational Biology to advance In VivoCAR-T programs and platform development. You will lead data-driven analyses across preclinical datasets, develop and benchmark methods, and contribute to capabilities spanning molecular modeling and AI-based therapeutic engineering.

The ideal candidate has a PhD and 3+ years in biotech or academia, with strong Python/R skills and a track record of leading computational projects while