Senior Scientist, Computational Biology & ML

Jobtailor; San Carlos (CA); On-site; USD 140,000 - 180,000; Full time

Job summary

Jobtailor seeks a senior bioinformatics scientist to analyze diverse biological datasets including NGS, long-read, single-cell, and antibody repertoire data. You will provide computational expertise across research teams and independently lead projects from questions to validation.

You will apply machine learning to biological data, evaluate protein language models for antibody discovery, and develop robust workflows for data processing and visualization.

Qualifications

• PhD or Master's degree with significant relevant experience in Bioinformatics, Computational Biology, Genomics, Biology, Immunology, or a related discipline.
• A minimum of 5+ years of experience.
• Prior industry experience is preferred.
• Strong experience analyzing next-generation sequencing datasets and developing bioinformatics workflows.
• Strong proficiency in Python and/or R and in a Unix/Linux command-line environment, including shell scripting and common bioinformatics tools.
• Strong quantitative reasoning, statistical analysis, data visualization, and scientific interpretation skills.
• Experience applying machine learning to biological data, including supervised learning, model training and evaluation, and interpretation of model performance.
• Experience with protein language models, sequence embeddings, fine-tuning, and other modern approaches for modeling biological sequences.
• Experience or interest in applying computational approaches across diverse areas of drug discovery and technology development, such as target and antibody discovery, structural biology, proteomics, and high-throughput screening.
• Demonstrated ability to independently formulate computational approaches, critically evaluate and validate results, troubleshoot problems, and drive projects to completion with strong attention to data quality and reproducibility.
• Excellent communication and collaboration skills, including the ability to work effectively with experimental and multidisciplinary teams, manage multiple priorities, and proactively communicate progress, timelines, and challenges.
• Ability to frequently drive to site locations with occasional travel within the United States.

Responsibilities

• Analyze and critically interpret diverse biological datasets, including next-generation, long-read, single-cell, and antibody repertoire sequencing data.
• Provide computational expertise across research teams to address bioinformatics and computational biology needs.
• Independently lead computational research and technology development projects from defining scientific questions and strategy through analysis, interpretation, and experimental validation.
• Apply machine learning approaches to biological datasets, including predictive modeling and modern deep learning approaches for biological sequences.
• Evaluate and apply protein language models and other biological foundation models to antibody discovery and development.
• Develop robust, reproducible computational workflows for processing, analyzing, integrating, and visualizing biological data.
• Collaborate with computational and experimental scientists to design studies, interpret results, troubleshoot unexpected findings, and guide subsequent experiments.
• Communicate project plans, progress, challenges, results, and recommendations to collaborators and stakeholders.
• Support antibody therapeutics discovery, technology development, and machine learning efforts at GigaGen.

Skills

Bioinformatics

Computational Biology

Next-Generation Sequencing

Machine Learning

Python

R

Unix/Linux

Shell Scripting

Data Visualization

Protein Language Models

Education

PhD or Master's degree in Bioinformatics/Computational Biology/Genomics/Immunology

Job description

Jobtailor seeks a senior bioinformatics scientist to analyze diverse biological datasets including NGS, long-read, single-cell, and antibody repertoire data. You will provide computational expertise across research teams and independently lead projects from questions to validation.

You will apply machine learning to biological data, evaluate protein language models for antibody discovery, and develop robust workflows for data processing and visualization.