Senior Scientist, Cell Therapy Process Scale-Up

BioSpace; Waltham (MA); On-site; USD 140,000 - 200,000; Full time

Job summary

Sanofi is seeking a Principal Scientist in Waltham, MA to join the Genomic Medicine Cell Therapy Process Development Group. You will lead scale-up activities from bench to pilot scales (200L-2000L) and guide process development for robust, scalable cell culture bioprocesses.

The role emphasizes hands-on lab work, cross-functional collaboration with downstream teams, and presenting findings to senior leaders.

Qualifications

• Masters degree in Chemical Engineering or related with 6+ years in large-scale bioreactors.
• Strong background in cell culture bioreactor operations and scale-up technologies.
• Experience in biotech/pharmaceutical industry within a cell culture role and an excellent understanding of operational excellence.
• Experience with perfusion process operations at various scales.
• Understanding of engineering principles related to cell culture process is required.

Responsibilities

• Lead scale-up activities from bench scale to pilot scale (200L-2000L).
• Collaborate with process development scientists to translate laboratory findings into scalable, robust manufacturing processes.
• Review and approve JSAs written by equipment owners and provide feedback.
• Train employees to adopt best practice for safety, efficiency and operational success.
• Build robust internal interfaces with the CMC community and promote adoption of best practices.
• Demonstrate expertise in upstream process operations at all scales.
• Lead root cause analysis (RCA) investigations for process deviations, equipment failures at pilot scale.
• Present findings and/or results to senior management, external stakeholders, and industry leaders at national/international conferences.

Skills

Bioreactor operations

Scale-up technologies

Perfusion processes

Process automation

Cross-functional collaboration

Education

Masters in Chemical Engineering

PhD in related field

Tools

None

Job description

Sanofi is seeking a Principal Scientist in Waltham, MA to join the Genomic Medicine Cell Therapy Process Development Group. You will lead scale-up activities from bench to pilot scales (200L-2000L) and guide process development for robust, scalable cell culture bioprocesses.

The role emphasizes hands-on lab work, cross-functional collaboration with downstream teams, and presenting findings to senior leaders.