Lead Scientist, Cell Therapy Process Development

Sanofi; Waltham (MA); On-site; USD 140,000 - 200,000; Full time

Job summary

Sanofi Inc. in Waltham, MA is seeking a Principal Scientist to lead cell culture process development for genomic medicine programs.

You will drive scale-up from bench to pilot scales (200L–2000L) and partner with development scientists to translate lab findings into robust manufacturing processes. The role requires a strong background in mammalian cell culture, bioreactor operations, perfusion processes, and hands‑on experience in bioprocess optimization, with a track record of leading matrix

Qualifications

• Master’s degree with 6+ years of experience in large-scale bioreactors or PhD with 4+ years in industry
• Strong background in cell culture bioreactor operations and scale-up technologies
• Experience in biotech/pharmaceutical industry within a cell culture role
• Experience with perfusion process operations at various scales
• Understanding of engineering principles related to cell culture process
• Ability to lead matrix teams for operations and lab management

Responsibilities

• Lead scale-up activities from bench scale to pilot scale (200L–2000L) applying engineering principles
• Collaborate with process development scientists to translate laboratory findings into scalable manufacturing processes
• Review and approve JSAs written by equipment owners and provide feedback
• Train employees to adopt best practices for safety, efficiency and operational success
• Build robust internal interfaces with the CMC community and promote best practices
• Demonstrate expertise in upstream process operations at all scales
• Lead RCA investigations for process deviations and equipment failures at pilot scale
• Present findings to senior management, external stakeholders, and industry leaders at conferences

Skills

Cell culture bioreactor operations

Scale-up technologies

Perfusion process operations

Engineering principles

Cross-functional collaboration

Process validation

Education

Master’s degree in Chemical Engineering or related

Ph.D. in a related field

Tools

Process automation tools

Job description

Sanofi Inc. in Waltham, MA is seeking a Principal Scientist to lead cell culture process development for genomic medicine programs.

You will drive scale-up from bench to pilot scales (200L–2000L) and partner with development scientists to translate lab findings into robust manufacturing processes. The role requires a strong background in mammalian cell culture, bioreactor operations, perfusion processes, and hands‑on experience in bioprocess optimization, with a track record of leading matrix