Head of Pilot Plant - Cell Therapy Process Scale-Up

Allogene Therapeutics; South San Francisco (CA); Presencial; USD 155.000 - 180.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Annual performance bonus

Equity

Health insurance

Generous time off

Holiday shutdowns

Descripción de la vacante

Allogene Therapeutics in South San Francisco is seeking a Principal Scientist to lead the Pilot Plant within Process & Product Development. You will translate development strategies into robust, at-scale cell therapy manufacturing operations and guide cross-functional teams including Drug Product, MSAT, and Manufacturing.

The role requires strong scientific leadership, experience with scale-up, DOE, and data-driven decision making, and the ability to drive technology transfer to GMP.

Formación

• Ph.D. in Chemical Engineering, Bioengineering, Biochemistry, Molecular & Cell Biology, Immunology, or related field with 7+ years of industry experience.
• Extensive experience in process development and scale-up for biologics or cell therapy manufacturing.
• Experience with DOE and data-driven decision making.
• Experience using Python or R for data analysis and automation development.
• Experience supporting regulatory filings (IND/BLA) and PPQ/process validation.
• Proven track record leading complex programs and cross-functional initiatives.
• Strong leadership, mentorship and cross-functional collaboration skills.
• Authorized to work in the U.S.

Responsabilidades

• Lead the Pilot Plant team and oversee large-scale and engineering runs.
• Translate development strategies into scalable at-scale cell therapy operations.
• Ensure alignment across development, pilot, and manufacturing for GMP transfer.
• Design and execute high-impact process development studies using QbD.
• Identify and mitigate scale-dependent risks in manufacturing platforms.
• Apply fluid dynamics, gas and mass transfer concepts to scale-up.
• Develop closed, aseptic automation strategies and optimize platform-specific systems.
• Drive end-to-end process integration for thaw, activation, expansion, fill/finish.
• Serve as primary Process Sciences interface with Drug Product, Manufacturing, MSAT.
• Document results in ELNs and technical reports; contribute to regulatory filings.
• Mentor scientists in study design, data interpretation, and decision-making.
• Stay current with cell therapy, immunology, and bioprocessing literature.
• Other duties as assigned.

Conocimientos

Leadership

Project management

Team mentoring

Data analysis

Educación

PhD in Chemical Engineering / Bioengineering / Biochemistry / Molecular & Cell Biology / Immunology or related field

Herramientas

Python

R

Descripción del empleo

Allogene Therapeutics in South San Francisco is seeking a Principal Scientist to lead the Pilot Plant within Process & Product Development. You will translate development strategies into robust, at-scale cell therapy manufacturing operations and guide cross-functional teams including Drug Product, MSAT, and Manufacturing.

The role requires strong scientific leadership, experience with scale-up, DOE, and data-driven decision making, and the ability to drive technology transfer to GMP.