Senior Scientist, Analytical Operations — Equity & Flexible PTO

DutchTechX; Emeryville (CA); On-site; USD 150,000 - 180,000; Full time

Benefits offered by this job

Equity package

Retirement plan

Flexible PTO

Medical insurance

Dental insurance

Vision insurance

Life insurance

Disability insurance

Career coaching

Mental health support

Free team lunches

Snacks

Social events

Job summary

Prolific Machines is seeking a Senior Scientist to execute and improve core analytical procedures for cell line and bioprocess development. You will balance hands-on lab work with resourcing, coordination, and people management to drive faster, more robust analytics.

You will apply chromatographic and electrophoretic methods (Protein A titer, SEC, RP/IEX, CE‑SDS, icIEF) and LC‑MS with MS data processing to inform clone selection and process decisions in a high‑volume setting.

Qualifications

• PhD or MS/BS with relevant biologics industry experience.

Responsibilities

• Manage day‑to‑day execution of core platform assays (Protein A titer, SEC, CE‑SDS, icIEF, intact/subunit mass).
• Coordinate research associates across projects; translate results into clone and process decisions.
• Remove bottlenecks across workflows from sample prep to data review.
• Own system suitability criteria, control standards, and performance trending; lead troubleshooting.
• Design, run, and interpret characterization studies (size/charge variants, PTMs, glycosylation, mass, mapping).
• Write and maintain methods, SOPs, templates, and reports ensuring data consistency.
• Maintain analytical instrumentation (HPLC/UPLC, CE, LC‑MS, QTOF, AKTA) and coordinate vendors.
• Train and mentor RAs and Scientists; set standards for execution and documentation.

Skills

5+ years biologics experience

Chromatographic methods

Electrophoretic methods

LC-MS characterization

Team leadership

Data interpretation & statistics

Education

PhD in Analytical Chemistry/ Biochemistry/ Chemistry/ Pharmaceutical Sciences

MS/BS with equivalent industry experience

Tools

HPLC/UPLC

CE

LC‑MS (protein)

Agilent QTOF

AKTA

Job description

Prolific Machines is seeking a Senior Scientist to execute and improve core analytical procedures for cell line and bioprocess development. You will balance hands-on lab work with resourcing, coordination, and people management to drive faster, more robust analytics.

You will apply chromatographic and electrophoretic methods (Protein A titer, SEC, RP/IEX, CE‑SDS, icIEF) and LC‑MS with MS data processing to inform clone selection and process decisions in a high‑volume setting.