Analytical Scientist I

DutchTech; Emeryville (CA); On-site; USD 120,000 - 140,000; Full time

Benefits offered by this job

Generous equity package

Retirement plan with company contribution

Flexible PTO

Company-covered medical, dental, and vision insurance

Career coaching

Free team lunches

Companywide social events

Job summary

DutchTech is seeking a talented scientist to join the Analytical Science team in Emeryville, California. In this role, you will collaborate with R&D and Bioprocess teams, focusing on the quantification and characterization of therapeutic proteins. The ideal candidate will hold a PhD and have industry experience in biologics.

The position offers a salary range of $120k-$140k, complemented by generous benefits, including medical, dental, vision, and a flexible PTO policy.

Qualifications

• 1+ years of biologics industry experience, preferably with a PhD.
• Experience in therapeutic protein characterization using HPLC, SDS, and LC-MS.
• Ability to perform aggregation and charge variant characterizations.

Responsibilities

• Develop and validate assays for protein quality and purity.
• Operate, maintain, and troubleshoot analytical instrumentation.
• Author and review methods, protocols, and standard operating procedures.

Skills

Protein quality attributes

HPLC

Mass spectrometry

Therapeutic protein characterization

Analytical Chemistry

Molecular Biology

Education

PhD in Analytical Chemistry or related field

Tools

Agilent QTOF

LC-MS

Job description

The Analytical Science team is looking for a talented scientist to collaboratively work with our R&D and Bioprocess teams to quantify and characterize broad classes of therapeutic proteins. A successful candidate will bring an outcome-oriented skillset to recombinant protein quantification and characterization. This role will be based on-site in Emeryville, CA.

Key Responsibilities

• Develop, optimize, and validate assays for protein quality and purity for broad classes of recombinant therapeutic proteins.
• Plan and execute experimentation to understand protein quality through cell line, upstream and downstream process development.
• Execute, summarize, and interpret routine and complex therapeutic protein characterizations.
• Qualify and validate assays upholding highly rigorous standards for execution and documentation.
• Routinely operate, maintain, and troubleshoot analytical instrumentation (HPLCs, FPLCs, mass spectrometers).
• Author, review, and implement methods, protocols, validations, and standard operating procedures.
• Ensure processes are followed in accordance with these standards.

Qualifications & Skills

• Hold a PhD in Analytical Chemistry, Molecular Biology, Biochemistry, Pharmaceutical Sciences, with 1+ years of biologics industry experience. Candidates without a PhD but with similar industry experience are encouraged to apply.
• Have illustrated experience in therapeutic protein characterization approaches (eg. HPLC, SDS, CE, cIEF, LC‑MS).
• Have illustrated the ability to develop, execute, and interpret intact mass, sequence confirmation, and PTM analysis (e.g., glycosylation, disulfide mapping, peptide mapping) through mass spectrometry.
• Have illustrated the ability to develop, execute, and interpret aggregation and charge variant characterizations for biologics.
• Have experience in the development and execution of GLP‑compliant methods characterizing protein quality attributes across a wide range of therapeutic classes.
• Have hands‑on experience operating LC‑MS. Experience with Agilent QTOF instrumentation applied to assay protein quality is a plus, including familiarity with proteomic software.
• Are highly motivated to deliver successful outcomes for internal and external clients.
• Are excited to work with internal and external clients to deliver project excellence.
• Have strong communication skills and are comfortable teaching and sharing knowledge at multiple levels of technical detail.

$120,000 - $140,000 a year

This role is salaried, exempt, and paid semi-monthly. Starting salary will be dependent upon specific experience, knowledge, and skillset. The range for the Scientist I level will typically fall between $120k-$140k.

Benefits

Generous equity package in an early stage company, retirement plan with company contribution, flexible PTO with healthy time off minimums, company‑covered medical, dental, and vision insurance, life and disability insurance, career coaching, mental health support, free team lunches everyday, great snacks, and companywide social events!

Diversity

Prolific Machines values diverse perspectives, backgrounds, experiences, and ideas. We are committed to building an inclusive workplace where all employees can bring their authentic selves to work and have equal opportunities to succeed. Prolific Machines is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, religion, creed, sex, gender identity or expression, sexual orientation, national origin, ancestry, age, disability, medical condition, genetic information, marital status, military or veteran status, or any other characteristic protected by applicable law.