Senior Scientist 3D Tissue High-Throughput Screening

Digital Biology; Watertown (MA); On-site; USD 140,000 - 190,000; Full time

Benefits offered by this job

Competitive salary

Equity

Benefits

Job summary

Digital Biology is seeking a Senior Scientist to contribute to our high-throughput drug screening platform for 3D human tissues. You will optimize assays, work with engineers and scientists to build scalable workflows, and drive robust, data-driven protocols in a hands-on wet-lab role.

You'll help design readouts, manage tissue handling and imaging, and communicate results to partners as we advance AI-guided protein discovery. This role is on-site in Watertown, MA.

Qualifications

• 3+ years of industry experience in biotech/pharma, with hands-on assay development and optimization.
• Ph.D. or equivalent in cell biology, bioengineering, molecular biology, or related field.
• Strong experience with organoids and/or 3D tissue models.
• Fluency in tissue handling, including sectioning, histology, and IHC/IF.
• Fluency in fluorescence and high-resolution microscopy.
• Deep experience in cell engineering, including CRISPR, and mammalian expression vector design and molecular cloning.
• A record of systematically optimizing complex, multi-step assays, with careful experimental design and troubleshooting.

Responsibilities

• Develop, optimize, and validate 3D tissue and organoid screening assays through structured, data-driven iteration cycles.
• Engineer and characterize immortalized and primary cell lines with advanced genetic tools, including CRISPR-based methods and histology.
• Design and build constructs and libraries for antibody and cell engineering.
• Own tissue handling end to end, including embedding, sectioning, histology, and staining.
• Run high-resolution imaging and spatial phenotyping, and ensure image data is quality-controlled and ready for analysis.
• Partner with automation engineers to scale workflows and improve throughput, reproducibility, cost, and turnaround time.
• Keep documentation, sample traceability, and data and metadata structure rigorous for downstream analysis and model training.
• Analyze data independently and present results, risks, and recommendations to the team and to partners.

Skills

3+ years biotech/pharma experience

Cell biology

Bioengineering

Molecular biology

Education

Ph.D. or equivalent

Tools

CRISPR

Histology

IHC/IF

Fluorescence microscopy

Job description

Digital Biology is seeking a Senior Scientist to contribute to our high-throughput drug screening platform for 3D human tissues. You will optimize assays, work with engineers and scientists to build scalable workflows, and drive robust, data-driven protocols in a hands-on wet-lab role.

You'll help design readouts, manage tissue handling and imaging, and communicate results to partners as we advance AI-guided protein discovery. This role is on-site in Watertown, MA.