Senior Research Scientist, RNA LNP Formulations

Contingent Workers; Carlsbad (CA); On-site; USD 58,000 - 103,000; Full time

Job summary

Ionis Pharmaceuticals, Inc. in Carlsbad, CA, seeks a Temp Senior Research Associate/Sr Scientist for Formulation and Delivery Sciences to join onsite nanoparticle formulation R&D.

The role involves synthesizing RNA-loaded lipid nanoparticles, performing physical-chemical characterizations, and assisting with biological testing in rodents and/or cell culture, with rigorous documentation and cross-functional collaboration to drive data quality.

Qualifications

• BS with 5+ years of relevant laboratory experience (Sr. RA level).
• PhD with 2+ years of relevant laboratory experience (Sr. Scientist).
• Experience synthesizing RNA-containing LNPs using microfluidic methods.
• Experience with Ribogreen, DLS, zeta potential; HPLC is a plus.
• Ability to learn rodent procedures (tail vein, necropsy).
• Strong teamwork and clear written/verbal communication.

Responsibilities

• Synthesize and document RNA-loaded lipid nanoparticles using microfluidic mixing.
• Perform particle analysis via Ribogreen, DLS and zeta potential.
• Assist with rodent dosing to assess safety/activity.
• Document results in electronic lab notebooks and analyze data.
• Maintain general laboratory organization and supplies.

Skills

RNA-loaded LNP synthesis

Ribogreen assay

DLS

Zeta potential

HPLC analysis

Rodent dosing procedures

Electronic lab notebooks

Team collaboration

Education

BS in life sciences or related

PhD in life sciences or related

Tools

Microfluidic mixing

Bench-scale purification

HPLC systems

Job description

Ionis Pharmaceuticals, Inc. in Carlsbad, CA, seeks a Temp Senior Research Associate/Sr Scientist for Formulation and Delivery Sciences to join onsite nanoparticle formulation R&D.

The role involves synthesizing RNA-loaded lipid nanoparticles, performing physical-chemical characterizations, and assisting with biological testing in rodents and/or cell culture, with rigorous documentation and cross-functional collaboration to drive data quality.