LNP Formulation Scientist II – Nucleic Acid Delivery

247Hire; San Diego (CA); On-site; USD 120,000 - 170,000; Full time

Job summary

247Hire is seeking a Scientist to join the Formulation team in San Diego. This hands-on role focuses on synthesizing and optimizing lipid nanoparticles for nucleic acid delivery, working closely with senior scientists to advance our non-viral delivery platform.

You will perform DoE-based screening to optimize LNP compositions, collaborate across teams, document results meticulously, and contribute to early-stage formulation development, stability studies, and routine lab management.

Qualifications

• Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 5+ years of biopharma industry experience, OR a Master's degree with 2+ years of industry experience.
• LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA) with 2+ years hands-on laboratory experience.
• Proficiency with LNP characterization methods: DLS, zeta potential, and Ribogreen assays.
• High proficiency in MS Excel.
• Strong attention to detail, reproducible data, and organizational skills.

Responsibilities

• Execute and optimize formulation and characterization of LNPs or tLNPs encapsulating nucleic acids for in vitro and in vivo studies.
• Implement DoE-based screening campaigns to optimize LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to fulfill formulation requests.
• Support early-stage formulation development, including cryoprotection, scale-up, and stability studies.
• Maintain detailed records documenting formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management: inventory, supplies, buffer prep, and autoclaving.

Skills

LNP formulation

Data analysis

MS Excel

Detail oriented

Team communication

Laboratory collaboration

Education

Bachelor's degree in Chemistry/Biochemistry/Chemical Engineering

Tools

Dynamic Light Scattering (DLS)

Zeta potential

RiboGreen assay

JMP

Prism

Job description

247Hire is seeking a Scientist to join the Formulation team in San Diego. This hands-on role focuses on synthesizing and optimizing lipid nanoparticles for nucleic acid delivery, working closely with senior scientists to advance our non-viral delivery platform.

You will perform DoE-based screening to optimize LNP compositions, collaborate across teams, document results meticulously, and contribute to early-stage formulation development, stability studies, and routine lab management.