Senior Research Scientist - Immunology & Genomics

Dovel Technologies, Inc; Bethesda (MD); On-site; USD 98,000 - 163,000; Full time

Benefits offered by this job

Medical

Dental & Vision Insurance

401(k) Retirement Plan

Tuition Reimbursement

Personal Development

Employee Referral Program

Job summary

Guidehouse is seeking a Research Scientist to support the National Heart, Lung, and Blood Institute in Bethesda, MD. The role includes immunology, molecular biology, and sequencing work across human and animal samples, with responsibilities spanning from bench to manuscript preparation.

The candidate will engage with multiple core facilities, present at meetings, and assist with regulatory documents. A PhD or MD-equivalent and 6+ years of experience are required for a fast-paced environment.

Qualifications

• Ph.D. or M.D. or other appropriate doctoral degree in science, medicine, or related field.
• Minimum of SIX (6) years of research experience in science, medicine, or related fields.
• Extensive experience in molecular biology, biochemistry, and immunology research, including experience in immune cell development and function.
• Experience generating knockout mice, conditional knockout mice, and extensive experience working with mice/mouse models.
• Extensive experience related to next generation sequencing methods and analyses (e.g., RNA-seq, scRNA-seq, ChIP-seq, ATAC-seq, Hi-C, HiChIP, PCA, UMAP, tSNE).
• Experience with advanced molecular biology techniques (e.g., ChIP, co-IP, advanced cloning techniques, western blotting, Northern blotting, Southern blotting, Q-PCR).
• Experience with flow cytometry, immunohistochemistry, and metabolomics.
• Extensive experience in cell culture and/or extensive knowledge of cell biology.
• Ability to manage and coordinate high-priority short- and long-term projects and studies in a fast-paced environment.

Responsibilities

• Perform immunology and molecular biology techniques with animal and human cells/tissues.
• Perform a range of biochemical assays, immunoprecipitations, PAGE and western blotting.
• Perform next generation sequencing techniques for transcriptomics and epigenetic analyses.
• Perform immunofluorescence staining and functional analyses of tissue samples.
• Work with sequencing, mass spectrometry, flow cytometry, and other cores as needed.
• Maintain mouse lines (breeding, genotyping).
• Present research at international and national research meetings.
• Assist the Lab Chief in creating/preparing required documents (CRADAs, MTAs, Patent Applications, Animal Protocols, BSC review).
• Review, edit, and write drafts of papers, posters and manuscripts.
• Act as scientific consultant and collaborator for IRTA fellows and Visiting Fellows.

Skills

Molecular biology

Immunology

Next-gen sequencing

Mouse models

Biochemical assays

Flow cytometry

Cell culture

Data presentation

Education

Ph.D. or M.D. or related doctoral degree

Tools

Flow cytometry

Mass spectrometry

Western blotting

Job description

Guidehouse is seeking a Research Scientist to support the National Heart, Lung, and Blood Institute in Bethesda, MD. The role includes immunology, molecular biology, and sequencing work across human and animal samples, with responsibilities spanning from bench to manuscript preparation.

The candidate will engage with multiple core facilities, present at meetings, and assist with regulatory documents. A PhD or MD-equivalent and 6+ years of experience are required for a fast-paced environment.