Senior Research Scientist

Yoh Services LLC; Philadelphia (Philadelphia County); On-site; USD 100,000 - 115,000; Full time

Benefits offered by this job

Medical, Prescription, Dental & Vision

Health Savings Account (HSA)

Life & Disability Insurance

MetLife Voluntary Benefits

Employee Assistance Program (EAP)

401K Retirement Savings Plan

Direct Deposit & weekly epayroll

Referral Bonus Programs

Certification and training

Job summary

Yoh Life Sciences in Philadelphia, PA seeks a Senior Research Scientist to lead tissue engineering and 3D bioprinting initiatives, driving assay development and client-ready research workflows for preclinical projects.

The role requires Ph.D. or MS with extensive biotech experience, 5+ years in leadership, and strong capability in primary human cell culture, sequencing analyses, and loop-optimization of lab protocols. Start September 2026 with a compensation range of $100,000–$115,000.

Qualifications

• Ph.D. in Bioengineering, Tissue Engineering, Cell Biology, Biotechnology, or a related discipline; alternatively an M.S. with extensive relevant industry experience.
• 5+ years of research experience with demonstrated scientific leadership in biotech, CRO, pharma, or related environment.
• Hands-on experience with primary human cell isolation, culture, expansion, and characterization.
• Experience with 3D bioprinting, tissue engineering, or multicellular model systems.
• Experience designing and optimizing laboratory assays, including ADME‑Tox and/or efficacy assays.
• Strong data analysis and interpretation skills; ability to draw clear conclusions from complex datasets.
• Experience with RNA sequencing or related molecular biology analyses.
• Excellent scientific documentation and communication abilities.
• Proven ability to lead projects, troubleshoot, and work independently in a fast-paced setting.

Responsibilities

• Lead implementation, optimization, and validation of 3D bioprinting protocols and bio-ink technologies.
• Support transfer of proprietary tissue engineering tech into U.S.-based lab workflows.
• Provide scientific leadership and mentorship to R&D teams.
• Lead development and optimization of high-throughput screening campaigns and assays.
• Design and develop multicellular tissue models to improve physiological relevance.
• Integrate multiple cell populations into advanced tissue models.
• Develop and validate customized workflows for commercial client projects.
• Analyze complex datasets to evaluate model performance and relevance.
• Oversee RNA sequencing and genomic fidelity data analyses.
• Troubleshoot protocols and identify efficiency improvements.
• Collaborate with cross-functional teams to advance platform development.
• Maintain high standards for scientific documentation and data integrity.

Skills

Tissue engineering

Primary human cell culture

3D bioprinting

Assay development

Scientific leadership

Data analysis

Cross-functional collaboration

Project leadership

Education

PhD in Bioengineering, Tissue Engineering, Cell Biology, Biotechnology, or related field

Tools

Automated 3D bioprinting systems

Microfluidic platforms

RNA sequencing data analysis

Genomic data analysis

Job description

Yoh Life Sciences is hiring for a Senior Research Scientist to join an innovative biotechnology company in Philadelphia, PA. This is an exciting opportunity for an experienced research scientist with expertise in tissue engineering, primary human cell culture, 3D bioprinting, and assay development to help establish and advance cutting‑edge precision medicine and preclinical research capabilities. This individual will provide scientific leadership across laboratory initiatives, drive assay and model development, and support the validation of research workflows for commercial client projects. The role offers the opportunity to help build and scale R&D capabilities within a rapidly growing biotechnology environment.

Location: Philadelphia, PA

Target Start Date: September 2026

Compensation: $100,000 – $115,000 annually

Key Responsibilities

• Lead the implementation, optimization, and validation of advanced 3D bioprinting protocols, bio‑ink technologies, and complex cell culture methodologies.
• Support the transfer of proprietary tissue engineering technologies and protocols into U.S.-based laboratory workflows.
• Provide scientific leadership and mentorship to R&D and laboratory team members.
• Lead the development and optimization of high‑throughput screening campaigns and research assays.
• Design and develop novel multicellular tissue models to improve the physiological relevance and reproducibility of 3D micro‑tumor systems.
• Integrate multiple cell populations, including fibroblasts, vascular cells, and immune cells, into advanced tissue models.
• Develop and validate customized research workflows in support of commercial client projects.
• Analyze and interpret complex experimental datasets to evaluate model performance, reproducibility, and biological relevance.
• Oversee analysis of RNA sequencing and genomic fidelity data to assess correlations between engineered tissue models and original patient biopsy samples.
• Troubleshoot experimental protocols and laboratory processes while identifying opportunities for improved efficiency and scientific performance.
• Collaborate with cross‑functional scientific and operational teams to advance platform development and client programs.
• Maintain high standards for scientific documentation, data integrity, and laboratory quality.

Qualifications

• Ph.D. in Bioengineering, Tissue Engineering, Cell Biology, Biotechnology, or a related scientific discipline; alternatively, an M.S. with extensive relevant industry experience.
• 5+ years of research experience with demonstrated scientific leadership within a biotechnology, CRO, pharmaceutical, cell therapy, or related environment.
• Strong hands‑on expertise with primary human cell isolation, culture, expansion, and characterization.
• Demonstrated experience with 3D bioprinting, tissue engineering, or advanced multicellular model systems.
• Experience designing, developing, and optimizing laboratory assays, including ADME‑Tox and/or efficacy assays.
• Strong understanding of experimental design, data analysis, and interpretation.
• Experience with genomic analysis, RNA sequencing data, or related molecular biology applications.
• Excellent scientific documentation and communication skills.
• Demonstrated ability to lead projects, troubleshoot complex scientific challenges, and work independently in a fast‑paced environment.

Preferred Experience

• Experience with automated 3D bioprinting systems and/or microfluidic platforms.
• Experience developing patient‑derived tumor models, organoids, or other huma‑relevant tissue models.
• Experience incorporating immune, vascular, and stromal cell populations into multicellular models.
• Experience working in a commercial biotechnology, CRO, or preclinical drug development environment.
• Experience supporting technology transfer from an international or external R&D organization into a U.S.-based laboratory.
• Familiarity with GxP, GLP, or other regulated research environments.

Estimated Min Rate

$100000.00

Estimated Max Rate

$115000.00

What’s In It for You?

• Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)
• Health Savings Account (HSA) (for employees working 20+ hours per week)
• Life & Disability Insurance (for employees working 20+ hours per week)
• MetLife Voluntary Benefits
• Employee Assistance Program (EAP)
• 401K Retirement Savings Plan
• Direct Deposit & weekly epayroll
• Referral Bonus Programs
• Certification and training opportunities

Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.

Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

Visit https://www.yoh.com/applicants-with-disabilities to contact us if you are an individual with a disability and require accommodation in the application process.

For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

By applying and submitting your resume, you authorize Yoh to review and reformat your resume to meet Yoh’s hiring clients’ preferences. To learn more about Yoh’s privacy practices, please see our Candidate Privacy Notice: https://www.yoh.com/privacy-notice