Senior Research Associate-Protein Assay Development – Spatial Biology

10x Genomics, Inc.; Pleasanton (CA); On-site; USD 90,000 - 120,000; Full time

Benefits offered by this job

Equity grants

Health benefits

Retirement plans

Annual bonus

Job summary

10x Genomics, Inc. seeks a Senior Research Associate to join the Spatial Team, advancing technologies that map proteins and other biomolecules within intact tissue.

You will collaborate with scientists to screen antibodies, optimize protocols, prepare libraries, operate instruments, and perform initial data analysis, ensuring top-quality results across the workflow. You will work with experts in spatial analysis, develop tools in spatial biology, and contribute to high-profile projects.

Qualifications

• BS/MS in Cell Biology, Immunology, Biomedical Sciences, Molecular Biology, or related field.
• 5+ years (BS) or 3+ years (MS) of hands-on industry experience.
• Experience with tissue processing, histology, immunohistochemistry, immunostaining, multiplex protein assays and/or in situ hybridization techniques.
• Experience working with antibodies and familiarity with mAb QC, conjugation and/or functional testing.
• Proven track record of using, optimizing and troubleshooting protocols in tissues.

Responsibilities

• Perform protein assays on tissue sections on microscope slides.
• Screen antibody clones via high-throughput fluorescent microscopy imaging and data pre-processing.
• Execute in situ library preparation workflows.
• Troubleshoot assays and optimize protocols for specific tissue samples.
• Deliver processed image data to computational biologists for analysis.
• Maintain documentation for project records.

Skills

Protein assays

Immunohistochemistry

Imaging analysis

Cross-functional collaboration

Coding basics

Education

BS/MS in Cell Biology/Immunology/Biomedical Sciences/Molecular Biology or related

Tools

CellProfiler

FIJI

High-throughput fluorescence microscopy

Job description

We're in search of an exceptional Senior Research Associate to join our Spatial Team. You'll be an integral part of our highly collaborative R&D team and contribute to developing technologies that map protein – and other biomolecules – directly within intact tissue. This will involve supporting all aspects of the process, including antibody clone screening, protocol optimization, library preparation, instrument operation, and initial analysis of the data, ensuring the highest quality results are achieved throughout the entire process. The successful candidate in this position will work closely with expert scientists in spatial analysis and will have the opportunity to participate in the development of high profile cutting edge tools in spatial biology.

You bring a strong background in the biological sciences and have acquired significant experience in conducting spatial assays to probe protein and RNA in tissues. You possess excellent communication skills, are detail oriented and can effectively collaborate with interdisciplinary teams, integrating feedback into your experimental design. Your high motivation, proactiveness, and adaptability allow you to navigate changing priorities and methods with ease. Thriving in fast-paced environments, you excel at managing multiple priorities, communicating clearly, and consistently delivering results.

What you will be doing

• Performing protein assays on tissue sections on microscope glass slides
• Antibody clone screening via high-throughput fluorescent microscopy imaging of the processed tissue samples, and image data pre-processing
• In situ library preparation workflows
• Participate in troubleshooting of assays and protocol optimization for specific tissue samples
• Deliver processed image data to and work closely with computational biologists for image data analysis
• Maintain relevant documentation for record keeping related to the projects

Minimum Requirements

• B.S. or M.S. in Cell Biology, Immunology, Biomedical Sciences, Molecular Biology, or a related scientific field.
• B.S. with 5+ years or M.S. with 3+ years of hands-on experience in an industry setting.
• Experience with tissue processing, histology, immunohistochemistry, immunostaining, multiplex protein assays and/or in situ hybridization techniques is a must
• Experience working with antibodies and familiarity with mAb QC, conjugation and/or functional testing is a must.
• A proven track record of using, optimizing and troubleshooting protocols in tissues.

Preferred Skills & Experience

• Tissue handling experience (fresh frozen, FFPE, antigen retrieval, etc.)
• Strong organizational skills and ability to plan and structure your work
• Excellent interpersonal skills, including written and oral communication
• Ability to work in a fast-paced and quickly changing environment
• Basic coding skills
• Experience with image analysis using relevant Software (e.g. CellProfiler, FIJI)
• Light and fluorescence microscopy experience (confocal or standard epifluorescence)
• Work experience from similar positions in academia, industry or a service provider/core facility

Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience. At 10x, base pay is also just one component of the Company’s total compensation package. This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company’s total compensation package.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.