Scientist 1, Protein Assay Development, Spatial Biology

10x Genomics, Inc.; Pleasanton (CA); Hybrid; USD 123,000 - 167,000; Full time

Benefits offered by this job

Equity grants

Health and retirement benefits

Annual bonus program

Job summary

10x Genomics, Inc. in Pleasanton, CA seeks a multidisciplinary scientist for Spatial Biology to map proteins and other biomolecules directly within intact tissue.

You will design, run, and troubleshoot experiments to develop spatial multiomics assays, collaborating with chemistry, computational biology, software and engineering teams. Ideal candidates will have a PhD in cell biology or related field and 2+ years in proteomics or in situ spatial techniques, with strong data analysis and

Qualifications

• PhD required in Cell Biology, Immunology, Biochemistry or related field.
• 2+ years hands-on experience in proteomics, in situ hybridization or other imaging based spatial techniques.
• Experience with tissue processing, histology, immunohistochemistry, cryosectioning, immunofluorescence including characterization by surface markers or gene expression.
• Experience working with antibodies, including mAb QC, conjugation and/or functional testing.
• Strong analytical background; excellent organizational, written and oral communication skills.
• Ability to thrive in a fast-paced, changing environment; strong troubleshooting skills.
• Desire to build game-changing technologies in life sciences.

Responsibilities

• Contribute to optimization of tissue handling and processing protocols for protein staining, including FFPE samples.
• Design and execute experiments using imaging and biochemistry platforms for spatial technology platforms.
• Analyze and report data via documentation and internal presentations.
• Collaborate with computational biologists and software engineers to interpret assay data.

Skills

Proteomics

In situ

IHC

Cryosectioning

Immunofluorescence

Antibody conjugation

Data analysis

Troubleshooting

Communication

Multiplex assays

R/Python

Education

PhD in Cell Biology or related field

Job description

About the role:

We are looking for an exceptional, multidisciplinary scientist to contribute to our product development efforts in our Spatial Biology department, developing technologies that map protein — and other biomolecules — directly within intact tissue. The ideal candidate will have a solid foundation in cell biology, immunology or tumor biology with strong troubleshooting skills and hands-on experience with tissue based imaging assays. This role will involve designing, running, and troubleshooting experiments to develop and optimize new assays in the area of spatial multiomics in tissues. You will collaborate closely with colleagues across chemistry, computational biology, software, engineering, and microfluidics to bring new products to life. We're looking for someone with strong analytical skills, curiosity about new technologies, and enthusiasm for working in a fast-paced, collaborative, multi-disciplinary environment.

What you will be doing:

Contribute to the optimization of tissue handling and processing protocols for protein staining, including FFPE samples, to improve antigen retention, staining consistency, and compatibility with high-plex imaging workflows.
Design and execute experiments using novel imaging and biochemistry platforms integral to various spatial technology platforms under development at 10x Genomics. This includes in-depth analysis and reporting of your data through documentation and presentations to internal groups.
Work closely with computational biologists and software engineers to interpret data generated by novel optical and biochemical assays.

Minimum Requirements:

• PhD in Cell Biology, Immunology, Biochemistry or related field.

• 2+ years of hands-on experience in proteomics, in situ hybridization or other imaging based spatial techniques.

• Experience with tissue processing, histology, immunohistochemistry, cryosectioning, immunofluorescence including characterization by surface markers or gene expression.

• Experience working with antibodies, including mAb QC, conjugation and/or functional testing.

• Strong analytical background

• Strong organizational skills.

• Strong written and oral communication skills.

• Strong troubleshooting and problem solving skills.

• Ability to work in a fast-paced and quickly changing environment.

• Desire to build game-changing technologies and impact the world of life science research.

Preferred Skills and Experience:

• Experience with multiplex protein assays is a plus

• Proficiency in R, Python, AI-aided coding or specialized omics data analysis software is a plus.

• Skills in image analysis are a plus.

Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience. At 10x, base pay is also just one component of the Company’s total compensation package. This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company’s total compensation package.

Pay Range

$123,100—$166,500 USD

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.
10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.