Senior Research Associate-Protein Assay Development - Spatial Biology

10x Genomics Inc; Pleasanton (CA); On-site; USD 110,000 - 150,000; Full time

Job summary

10x Genomics Inc. is seeking a Senior Research Associate to join the Spatial Team. You will perform protein assays on tissue sections, screen antibody clones, and support in situ library prep while collaborating with computational biologists on image data analysis.

The role requires hands-on tissue processing and immunostaining experience, strong communication, and the ability to thrive in a fast-paced environment.

Qualifications

• BS or MS in a relevant biological field such as cell biology or immunology.
• 5+ years (BS) or 3+ years (MS) of hands-on industry experience.
• Experience with tissue processing, histology, IHC, immunostaining, multiplex protein assays and/or in situ hybridization.
• Experience with antibodies and familiarity with mAb QC, conjugation and/or functional testing.

Responsibilities

• Perform protein assays on tissue sections.
• Antibody clone screening via high-throughput fluorescence imaging and data pre-processing.
• In situ library preparation workflows.
• Troubleshoot assays and optimize protocols.
• Deliver processed image data for analysis with computational biologists.
• Maintain documentation for project records.

Skills

Protein assays

Tissue processing

Immunohistochemistry

Antibody QC

Image analysis

Protocol troubleshooting

Data analysis

Documentation

Education

Bachelor's or MS in Cell Biology/ Immunology/ Biomedical Sciences/ Molecular Biology

Tools

CellProfiler

FIJI

Confocal microscopy

Job description

About the role:

We're in search of an exceptional Senior Research Associate to join our Spatial Team. You'll be an integral part of our highly collaborative R&D team and contribute to developing technologies that map protein - and other biomolecules - directly within intact tissue. This will involve supporting all aspects of the process, including antibody clone screening, protocol optimization, library preparation, instrument operation, and initial analysis of the data, ensuring the highest quality results are achieved throughout the entire process. The successful candidate in this position will work closely with expert scientists in spatial analysis and will have the opportunity to participate in the development of high profile cutting edge tools in spatial biology.

You bring a strong background in the biological sciences and have acquired significant experience in conducting spatial assays to probe protein and RNA in tissues. You possess excellent communication skills, are detail oriented and can effectively collaborate with interdisciplinary teams, integrating feedback into your experimental design. Your high motivation, proactiveness, and adaptability allow you to navigate changing priorities and methods with ease. Thriving in fast-paced environments, you excel at managing multiple priorities, communicating clearly, and consistently delivering results.

What you will be doing:

• Performing protein assays on tissue sections on microscope glass slides
• Antibody clone screening via high-throughput fluorescent microscopy imaging of the processed tissue samples, and image data pre-processing
• In situ library preparation workflows
• Participate in troubleshooting of assays and protocol optimization for specific tissue samples
• Deliver processed image data to and work closely with computational biologists for image data analysis
• Maintain relevant documentation for record keeping related to the projects

Minimum Requirements:

• B.S. or M.S. in Cell Biology, Immunology, Biomedical Sciences, Molecular Biology, or a related scientific field.
• B.S. with 5+ years or M.S. with 3+ years of hands‑on experience in an industry setting.
• Experience with tissue processing, histology, immunohistochemistry, immunostaining, multiplex protein assays and/or in situ hybridization techniques is a must
• Experience working with antibodies and familiarity with mAb QC, conjugation and/or functional testing is a must.
• A proven track record of using, optimizing and troubleshooting protocols in tissues.

Preferred Skills & Experience:

• Tissue handling experience (fresh frozen, FFPE, antigen retrieval, etc.)
• Strong organizational skills and ability to plan and structure your work
• Excellent interpersonal skills, including written and oral communication
• Ability to work in a fast-paced and quickly changing environment
• Basic coding skills
• Experience with image analysis using relevant Software (e.g. CellProfiler, FIJI)
• Light and fluorescence microscopy experience (confocal or standard epifluorescence)
• Work experience from similar positions in academia, industry or a service provider/core facility

Below is the base pay range for this full‑time position. The actual base pay will depend on several factors unique to each candidate, including one's skills, qualifications, and experience. At 10x, base pay is also just one component of the Company's total compensation package. This role is also eligible for 10x's equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company's total compensation package.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.