Analytical Development Scientist

10x Genomics Inc; Pleasanton (CA); On-site; USD 123,000 - 167,000; Full time

Job summary

10x Genomics Inc is seeking an Analytical Development Scientist to lead the development and implementation of QC assays for single cell and spatial biology products. You will design end-to-end QC strategies from materials to finished goods and optimize current methods while collaborating with R&D and Manufacturing teams globally.

The role requires deep analytical chemistry and molecular biology experience, strong documentation skills, and effective cross-functional communication to drive quality

Qualifications

• PhD or MS in Molecular Biology, Biochemistry, Organic Chemistry, Analytical Chemistry, or related fields.
• 2+ years (PhD) or 5+ years (MS) in biotechnology or analytical chemistry industrial experience.
• Experience designing, developing, and implementing QC strategies from raw materials to finished products.
• Hands-on experience with analytical chemistry and/or molecular biology techniques such as characterization and quantification of oligonucleotides, proteins, enzymes, antibodies, and small molecules.
• Development of HPLC methods for characterization of small molecules.
• Experience with PCR and qPCR for quantification.
• Demonstrated ability to document and transfer complex analytical assays into manufacturing and QC environments.
• Strong collaboration and communication skills across technical and non-technical teams.

Responsibilities

• Lead development, validation, and implementation of QC methods for single cell and spatial biology products.
• Design, document, and implement end-to-end QC strategies from materials to finished goods.
• Optimize and improve existing QC strategies and methods.
• Train QC teams domestically and internationally on analytical assays and compliance.
• Troubleshoot product formulation, storage, and QC issues.
• Design experiments to understand molecular interactions and root causes using DOE or similar methods.
• Document and update SOPs and present findings to cross-functional teams.

Skills

Mass spectrometry

LC/MS

qPCR

PCR

Molecular biology

Analytical chemistry

DOE (Design of Experiments)

SOP documentation

Cross-functional collaboration

Education

PhD in Molecular Biology

MS in Chemistry or related field

Tools

HPLC

Flow cytometry

Gel electrophoresis

JMP or R

Job description

About the Role:

We are seeking a highly skilled and motivated Analytical Development Scientist to join the Reagent and Analytical Development team at 10x Genomics. This role will focus on the development and implementation of quality control assays and workflows for single cell and spatial biology products, with a strong emphasis on analytical chemistry skills. The successful candidate will work closely with R&D and Manufacturing teams both domestically and internationally to ensure the highest quality standards for 10x products are met from concept through post-launch activities.

What you will be doing:

• Lead and collaborate on the development, validation, and implementation of novel and/or orthogonal quality control methods for molecular biology products across single cell and spatial biology technology platforms
• Design, documentation, and implementation of end-to-end QC strategies from raw materials to finished goods that are efficient and cost effective
• Optimization and continuous improvement of existing QC strategies and methods
• Train QC team members domestically and internationally on complex analytical assays with reassessment and retraining for compliance as needed
• Independently troubleshoot and resolve issues related to product formulation, customer escalations, long-term storage, and quality control
• Design and conduct experiments to understand molecular interactions within complex systems, including cause and effect, root cause of failure modes, guardbanding for manufacturing workflows, and optimization using Design of Experiments (DOE) methodologies or other statistically driven approaches
• Document and update standard operating procedures (SOPs)
• Present key findings to cross functional teams and leadership

Minimum Requirements:

• PhD or MS in Molecular Biology, Biochemistry, Organic Chemistry, Analytical Chemistry, or related fields
• 2+ years (PhD) or 5+ years (MS) of relevant biotechnology or analytical chemistry industrial experience
• Demonstrated experience designing, developing, and implementing QC strategies from raw materials to finished products
• Deep understanding and hands‑on experience with application of analytical chemistry and/or molecular biology techniques such as:
  • Characterization and quantification of oligonucleotides via direct mass spectroscopy, LC/MS, and other advanced analytical methods
  • Characterization and quantification of proteins and enzymes via mass spectroscopy, LC/MS, and kinetic/thermodynamic assays
  • Characterization of antibodies via flow cytometry, gel electrophoresis, and other advanced analytical techniques
  • Development of HPLC methods for characterization of small molecules
  • Separation and characterization of complex mixtures of biological molecules to support protein purification development efforts
  • PCR
  • qPCR techniques for quantification via dye & probe-based approaches
• Demonstrated success in developing, optimizing, and troubleshooting analytical chemistry assays
• Experience developing and implementing novel quality control assays to assess performance in functional and orthogonal assays
• Demonstrated ability to document and transfer complex analytical assays into manufacturing and quality control environments
• Strong collaboration and communication skills across technical and non‑technical portions of the organization
• Ability to manage multiple priorities and provide clear communication and recommendations around scientific results

Preferred Skills & Background:

• Direct experience developing or working with single cell and/or spatial biology products
• Experience working in ISO 9001 or ISO 13485 environments
• Experience using statistical tools, such as JMP or R, to analyze complex data sets and create DOE experiments
• Experience automating analytical analyses and reports
• Previous experience supervising and/or mentoring junior staff
• Previous work communicating and troubleshooting quality control issues with external suppliers
• Hands‑on experience with 10x Genomics products

Salary Range: $123,100 - $166,500

Below is the base pay range for this full‑time position. The actual base pay will depend on several factors unique to each candidate, including one's skills, qualifications, and experience. At 10x, base pay is also just one component of the Company's total compensation package. This role is also eligible for 10x's equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company's total compensation package.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law. 10x does not accept unsolicited applicants submitted by third‑party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.