Senior Research Associate, Muscle AAV Gene Therapy

Dyno Therapeutics; Watertown (MA); On-site; USD 96,000 - 116,000; Full time

Benefits offered by this job

Annual bonus

Stock options

Medical, dental, and vision coverage

401(k) plan

Flexible paid time off

On-campus gym membership

Onsite lunch

Commuter support

Company provided laptop

Job summary

Dyno Therapeutics is seeking a Senior Research Associate to advance animal studies and identify muscle AAV-based capsids. You will process tissues from in vivo studies, support histology workflows, and perform in vitro experiments to characterize leading capsids and libraries.

You will work with a cross-functional team of scientists, optimize workflows, troubleshoot issues, and ensure high-quality data to inform gene therapy programs.

Qualifications

• BS or MS in biology, biochemistry, biomedical engineering, or related fields.
• At least 3 years of full-time, post-graduate wet-lab experience.
• Experience in DNA/RNA purification and analysis protocols (qPCR, RT-qPCR).
• Experience handling mammalian tissues or other complex biological samples.
• Ability to execute complex protocols with high accuracy and attention to detail.

Responsibilities

• Sample inventory and dissection of tissues (mammalian cells, non-human primate and mouse tissues).
• Extract, purify, and enrich nucleic acids from mammalian cells and tissues.
• Run quantification assays on purified nucleic acids (e.g., qPCR, RT-qPCR).
• Prepare next-generation sequencing libraries (amplicon sequencing) and perform QC steps.
• Support histology workflows, including tissue preparation, sectioning, staining, imaging, and analysis.
• Maintain mammalian cell cultures and execute cell-based experiments to characterize leading muscle capsids and capsid libraries.
• Analyze experimental data, identify technical issues, and recommend next steps in collaboration with project leads.
• Maintain detailed and accurate records using ELN and LIMS.
• Communicate findings clearly and collaborate across experimental and computational teams to achieve goals.
• Adhere to lab protocols and safety regulations.

Skills

Molecular biology

Tissue processing

Histology

Cell culture

qPCR

In vitro assays

Data analysis

Lab documentation

Cross-functional collaboration

Education

BS/MS in biology/biochemistry/biomedical engineering

Tools

Benchling

LIMS

Job description

Dyno Therapeutics is seeking a Senior Research Associate to advance animal studies and identify muscle AAV-based capsids. You will process tissues from in vivo studies, support histology workflows, and perform in vitro experiments to characterize leading capsids and libraries.

You will work with a cross-functional team of scientists, optimize workflows, troubleshoot issues, and ensure high-quality data to inform gene therapy programs.