Senior Research Associate, Immunology

nant; Louisville (CO); On-site; USD 70,000 - 95,000; Full time

Job summary

ImmunityBio is seeking a Senior Research Associate to develop and optimize experiments for biologics research. You will support recombinant protein work from microbial hosts and contribute to immuno-therapeutics programs.

The role focuses on designing experiments, cell line development, and analytical assays, with emphasis on data-driven conclusions and documentation in lab notebooks. Collaborative, cross-functional team environment with hands-on lab duties.

Qualifications

• Bachelor's degree with 5+ years of industry experience or Master's with 3+ years.
• Experience in microbial cell culture and transformation techniques.
• Experience in molecular biology techniques (PCR, cloning, gel electrophoresis, sequence analysis, Western Blot).
• Experience with protein purification and/or analytical assays (e.g. HPLC).

Responsibilities

• Design, plan and conduct experiments to answer scientific questions with accuracy and precision.
• Identify problems proactively while analyzing data and troubleshoot with minimal guidance.
• Adhere to complex protocols; write core protocols and generate study reports as assigned.
• Support development of new biologics through molecular cloning, cell line development, functional testing, characterization and banking of microbial cell lines.
• Implement and optimize cell-based assays to assess the function of prospective products.
• Maintain mammalian and microbial cell cultures, and assist with fermentation.
• Conduct protein extraction, purification and analytics (e.g. chromatography, HPLC, SDS-PAGE).
• Communicate results effectively via reports and presentations; document methods and results in notebooks.

Skills

Microbial culture

Molecular biology

PCR & cloning

Protein purification

Analytical assays

Data presentation

Problem solving

Laboratory organization

Education

Bachelor's degree in science

Master's degree in science

Tools

PCR machines

HPLC

Cell culture equipment

Job description

Company Overview

ImmunityBio is a vertically integrated commercial stage biotechnology company developing next-generation therapies that bolster the natural immune system to defeat cancers and infectious diseases. The Company's range of immunotherapy and cell therapy platforms, alone and together, act to drive and sustain an immune response with the goal of creating durable and safe protection against disease. Designated an FDA Breakthrough Therapy, ANKTIVA is the first FDA-approved immunotherapy for non-muscle invasive bladder cancer CIS that activates NK cells, T cells, and memory T cells for a long-duration response. The Company is applying its science and platforms to treating cancers, including the development of potential cancer vaccines, as well as developing immunotherapies and cell therapies that we believe sharply reduce or eliminate the need for standard high-dose chemotherapy. These platforms and their associated product candidates are designed to be more effective, accessible, and easily administered than current standards of care in oncology and infectious diseases.

Why ImmunityBio?

• ImmunityBio is developing cutting-edge technology with the goal to transform the lives of patients with cancer and develop next-generation therapies and vaccines that complement, harness and amplify the immune system to defeat cancers and infectious diseases.
• Opportunity to join a publicly traded biopharmaceutical company with headquarters in Southern California.
• Work with a collaborative team with the ability to work across different areas of the company.
• Ability to join a growing company with professional development opportunities.

Position Summary

The Senior Research Associate is responsible for developing, conducting and optimizing everyday experiments to support the discovery and development of biologics for the research and development (R&D) group, as well as for supporting the efficient operation of the laboratory. They contribute directly to the development and characterization of recombinant proteins produced from microbial hosts and their role has an important impact on the progress of the company's immuno-therapeutics program.

Essential Functions

• Design, plan and conduct experiments to answer scientific questions with accuracy and precision
• Identify problems proactively while analyzing data and during experimental execution, and troubleshoot with minimal guidance
• Adhere to complex protocols or techniques; with assistance, write core protocols and generate study reports as assigned
• Support development of new biologics through molecular cloning, cell line development, functional testing, characterization and banking of microbial cell lines
• Implement and optimize cell-based assays to assess the function of prospective products
• Maintain mammalian and microbial cell cultures, and assist with fermentation
• Conduct protein extraction, purification and analytics (e.g. chromatography, HPLC, SDS-PAGE)
• Analyze data and devise simple conclusions; compile, organize, and present data at group meetings
• Communicate results effectively in a timely manner via reports and presentations; accurately document experimental methods and results in laboratory notebooks
• Contribute data, reagents, or hands-on support to other projects needed for the advancement of products in the pipeline
• Research literature on an assigned topic and effectively summarize data and findings
• Support the lab by performing activities such as maintaining lab equipment, ordering and stocking supplies, and maintaining inventory
• Support preclinical studies by evaluating basic health status of animals and reporting abnormalities to the appropriate personnel and assist with vivarium maintenance
• Performs ad-hoc and cross-functional duties and/or projects as assigned to support business needs and provide developmental opportunities.

Education & Experience

• Bachelor's degree in a scientific discipline with 5+ years of industry experience required; or Master's degree in a scientific discipline with 3+ years of industry experience required
• Experience in microbial cell culture and transformation techniques required
• Experience with fermentation preferred
• Experience in molecular biology techniques (PCR, cloning, gel electrophoresis, sequence analysis, Western Blot) required
• Experience with protein purification and/or analytical assays (e.g. HPLC) preferred
• Prior experience working with small rodent models preferred

Knowledge, Skills, & Abilities

• Ability to plan and perform various experiments with accuracy, precision, and minimal guidance from supervisor
• Capable of explaining the overall goal of an experiment, and to integrate literature searches to further inform understanding
• Strong attention to detail, organization and critical thinking skills
• Ability to troubleshoot and solve problems independently as well as analyze data and reach a simple conclusion
• Ability to independently prepare data presentations for group meetings
• Ability to keep an organized la